Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Penicillin v
Drug ID BADD_D01715
Description Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK.[A178609] It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin]. An orally active naturally penicillin, phenoxymethylpenicillin is used to treat mild to moderate infections in the respiratory tract, skin, and soft tissues caused by penicillin G­-sensitive microorganisms. Phenoxymethylpenicillin has also be used in some cases as prophylaxis against susceptible organisms. While there have been no controlled clinical efficacy studies that were conducted, phenoxymethylpenicillin has been suggested by the American Heart Association and the American Dental Association for use as an oral regimen for prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract, except for those who are at an elevated risk for endocarditis.[label]
Indications and Usage Indicated for the treatment of mild to moderately severe infections due to penicillin G­-sensitive microorganisms, with the use of bacteriological studies (including sensitivity tests) and clinical response.[label] Phenoxymethylpenicillin may be used for the treatment of: - mild to moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas caused by Streptococcus without bacteremia - mild to moderately severe infections of the respiratory tract caused by Pneumococcus - mild infections of the skin and soft tissues caused by penicillin G-sensitive Staphylococcus - mild to moderately severe infections of the oropharynx caused by Fusospirochetosis, including Vincent’s gingivitis and pharyngitis, usually respond to oral penicillin therapy **Off-label** Indicated for use as prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract.[label]
Marketing Status approved; vet_approved
ATC Code J01CE02
DrugBank ID DB00417
KEGG ID D05411
MeSH ID D010404
PubChem ID 6869
TTD Drug ID D09CPR
NDC Product Code Not Available
UNII Z61I075U2W
Synonyms Penicillin V | Fenoxymethylpenicillin | Phenoxymethylpenicillin | Penicillin, Phenoxymethyl | Phenoxymethyl Penicillin | Beromycin | Beromycin, Penicillin | Penicillin Beromycin | Berromycin, Penicillin | Penicillin Berromycin | Betapen | Pen VK | Penicillin VK | Penicillin V Sodium | Sodium, Penicillin V | V Sodium, Penicillin | V-Cillin K | V Cillin K | VCillin K | Vegacillin | Apocillin | Penicillin V Potassium | Potassium, Penicillin V
Chemical Information
Molecular Formula C16H18N2O5S
CAS Registry Number 87-08-1
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)COC3=CC=CC=C3)C(=O)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema08.01.07.006; 14.05.06.010---
Panic attack19.06.04.001---
Pruritus23.03.12.0010.000525%
Psychomotor hyperactivity17.01.02.011; 19.11.02.0030.000083%-
Pyrexia08.05.02.0030.000177%
Rash23.03.13.0010.002558%-
Rash erythematous23.03.13.029---
Rash maculo-papular23.03.13.004--
Rash papular23.03.13.017---
Rash pruritic23.03.13.0300.000122%-
Serum sickness10.01.03.004; 12.02.08.004--
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.0070.000083%
Swelling08.01.03.0150.000326%-
Swelling face08.01.03.100; 10.01.05.018; 23.04.01.0180.000193%-
Syncope02.11.04.015; 17.02.04.008; 24.06.02.012--
Thrombocytopenia01.08.01.002---
Tongue discolouration07.14.02.006---
Tooth discolouration07.09.02.001--
Urticaria10.01.06.001; 23.04.02.0010.002525%
Vasculitis10.02.02.006; 24.12.04.027--
Vomiting07.01.07.0030.000337%
Adverse event08.06.01.0100.000188%-
Adverse drug reaction08.06.01.0090.000177%-
Liver injury09.01.07.022; 12.01.17.0120.000387%-
Oropharyngeal pain07.05.05.004; 22.12.03.016--
Respiratory tract oedema22.02.07.0130.000055%-
Reaction to excipient10.01.01.0420.000055%-
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ADReCS-Target
Drug Name ADR Term Target
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