Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Infestation11.09.01.001; 23.11.01.002---
Inflammation08.01.05.007; 10.02.01.0890.000504%-
Limb discomfort15.03.04.0140.000526%-
Intra-abdominal haemorrhage07.12.02.008; 12.01.17.011; 24.07.02.0350.000280%
Ischaemic stroke17.08.01.018; 24.04.06.010---
Malnutrition14.03.02.0040.000224%-
Mediastinal disorder22.09.03.001---
Mental disorder19.07.01.002---
Metastatic neoplasm16.16.01.0070.000358%-
Motor dysfunction15.05.06.006; 17.01.02.0310.000414%-
Neoplasm progression16.16.02.0050.003156%-
Decreased appetite08.01.09.028; 14.03.01.0050.028251%
Gastrointestinal ulcer07.04.04.0020.000246%-
Renal neoplasm16.08.03.001; 20.01.04.0040.000224%-
Ill-defined disorder08.01.03.0490.000884%-
Polyp08.01.06.010; 16.02.02.0050.000112%-
Blood disorder01.05.01.0040.000168%-
Disease progression08.01.03.0380.019632%
Drug intolerance08.06.01.013---
Hepatic lesion09.01.08.0050.000224%-
Hepatobiliary disease09.01.08.003---
Lung neoplasm16.19.04.001; 22.08.01.0060.000168%-
Pigmentation disorder23.05.03.0010.000548%-
Metastasis16.22.01.0010.000783%-
Microangiopathy24.03.02.0210.000112%-
Renal impairment20.01.03.0100.003716%-
Hypophagia07.01.06.010; 14.03.01.006; 19.09.01.0040.000448%-
Tumour invasion16.16.01.0080.000168%-
Exfoliative rash23.03.07.006---
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.000560%
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