Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Parecoxib
Drug ID BADD_D01674
Description Parecoxib is a water-soluble and injectable prodrug of valdecoxib. It is marketed as Dynastat in the European Union. Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx). As it is injectable, it can be used perioperatively when patients are unable to take oral medications. It is approved through much of Europe for short term perioperative pain control much in the same way ketorolac (Toradol) is used in the United States. A letter of non-approval for parecoxib was issued by the FDA in 2005.
Indications and Usage Used for short term perioperative pain control.
Marketing Status approved
ATC Code M01AH04
DrugBank ID DB08439
KEGG ID D03716
MeSH ID C409945
PubChem ID 119828
TTD Drug ID D05UWI
NDC Product Code Not Available
UNII 9TUW81Y3CE
Synonyms parecoxib | N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamide | N-(((Me-P)-P)S)P | parecoxib sodium | N-(((5-methyl-3-phenylisoxazol-4-yl)-phenyl)sulfonyl)propanamine, sodium salt | Dynastat
Chemical Information
Molecular Formula C19H18N2O4S
CAS Registry Number 198470-84-7
SMILES CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory failure14.01.04.003; 22.02.06.002--
Shock24.06.02.002---
Skin disorder23.03.03.007---
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Swelling08.01.03.015---
Tachycardia02.03.02.007---
Thrombocytopenia01.08.01.002---
Toxic epidermal necrolysis10.01.01.006; 11.07.01.006; 12.03.01.015; 23.03.01.008--
Ulcer08.03.06.001---
Urethral disorder20.07.01.002---
Urinary tract disorder20.08.01.001---
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Wound infection11.01.08.010; 12.01.08.012--
Anaemia postoperative01.03.02.014; 12.02.05.032---
Acute coronary syndrome02.02.02.015; 24.04.04.011---
Lymphatic disorder01.09.01.003---
Musculoskeletal discomfort15.03.04.001---
Post procedural complication12.02.05.018---
Angiopathy24.03.02.007---
Cardiac disorder02.11.01.003---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Infestation11.09.01.001; 23.11.01.002---
Malnutrition14.03.02.004---
Mediastinal disorder22.09.03.001---
Decreased appetite08.01.09.028; 14.03.01.005--
Inner ear disorder04.04.02.002---
Blood disorder01.05.01.004---
Alveolar osteitis07.09.01.006; 11.01.04.010; 15.02.04.017---
Gastrointestinal sounds abnormal07.01.01.002---
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