Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Nevirapine
Drug ID BADD_D01557
Description A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Indications and Usage For use in combination with other antiretroviral drugs in the ongoing treatment of HIV-1 infection.
Marketing Status approved
ATC Code J05AG01
DrugBank ID DB00238
KEGG ID D00435
MeSH ID D019829
PubChem ID 4463
TTD Drug ID D0O2EM
NDC Product Code 53104-7546; 70159-002; 65862-027; 0378-4050; 64380-709; 65862-932; 65862-933; 31722-505; 65862-057; 68554-0044; 33342-004; 0597-0047; 64220-102; 0378-4890; 65162-209; 33342-238; 42571-131
UNII 99DK7FVK1H
Synonyms Nevirapine | Nevirapine Hemihydrate | Hemihydrate, Nevirapine | Viramune | BI-RG-587 | BI RG 587 | BIRG587
Chemical Information
Molecular Formula C15H14N4O
CAS Registry Number 129618-40-2
SMILES CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004---
Hepatitis acute09.01.07.0050.003978%-
Hepatitis cholestatic09.01.01.0020.005304%-
Hepatitis fulminant09.01.07.007; 11.07.01.003---
Hepatitis toxic09.01.07.017; 12.03.01.016---
Hepatocellular injury09.01.07.0080.003978%-
Hepatotoxicity09.01.07.009; 12.03.01.0080.005304%-
Hypercholesterolaemia14.08.01.001---
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hyperlactacidaemia14.01.01.006---
Hypersensitivity10.01.03.0030.002652%
Hypertension24.08.02.0010.007956%
Hypertriglyceridaemia14.08.02.001--
Immune system disorder10.02.01.001---
Influenza like illness08.01.03.0100.005304%
Insulin resistance05.06.02.003; 14.06.02.003---
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Liver disorder09.01.08.001---
Liver function test abnormal13.03.04.030---
Lymphadenopathy01.09.01.002---
Malaise08.01.01.003--
Mouth ulceration07.05.06.0040.002652%-
Myalgia15.05.02.0010.002652%
Myocardial infarction02.02.02.007; 24.04.04.0090.013260%
Nausea07.01.07.001--
Necrosis08.03.03.001; 24.04.02.006---
Neoplasm malignant16.16.01.0010.002652%-
Nervous system disorder17.02.10.001---
Neuropathy peripheral17.09.03.003---
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ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene