| Drug Name |
Minocycline hydrochloride |
| Drug ID |
BADD_D01472 |
| Description |
Minocycline was first described in the literacture in 1966.[A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.[A190723]
Minocycline was granted FDA approval on 30 June 1971.[L11695] |
| Indications and Usage |
Oral and topical minocycline are indicated to treat inflammatory lesions of acne vulgaris.[L11701,L11704,L11719] Subgingival microspheres are indicated as an adjunct treatment in the reduction of pocket depth in adults with periodontitis.[L11716] Oral and intravenous formulations are indicated to treat infections of susceptible microorganisms.[L11707,L11710,L11713] These include rickettsiae, _Mycoplasma pneumoniae_, _Chlamydia trachomatis_, _Chlamydophila psittaci_, _Chlamydia trachomatis_, _Ureaplasma urealyticum_, _Borrelia recurrentis_, _Haemophilus ducreyi_, _Yersinia pestis_, _Francisella tularensis_, _Vibrio cholerae_, _Campylobacter fetus_, _Brucella_ species, _Bartonella bacilliformis_, _Klebsiella granulomatis_, _Escherichia coli_, _Enterobacter aerogenes_, _Shigella_ species, _Acinetobacter_ species, _Haemophilus influenzae_, and _Kelbsiella_ species.[L11710] |
| Marketing Status |
approved; investigational |
| ATC Code |
J01AA08; A01AB23; D10AF07 |
| DrugBank ID |
DB01017
|
| KEGG ID |
D00850
|
| MeSH ID |
D008911
|
| PubChem ID |
54685925
|
| TTD Drug ID |
D08LTU
|
| NDC Product Code |
50909-9201; 65862-554; 42546-771; 55111-639; 57664-852; 64380-156; 68071-2225; 68071-2866; 68180-381; 68382-531; 69489-122; 70934-802; 72143-223; 0781-5387; 99207-464; 99207-467; 44657-0081; 65862-557; 0115-9936; 42546-777; 55111-637; 57664-853; 61919-270; 63629-9214; 65862-884; 65976-100; 67877-436; 67877-576; 68071-2311; 68382-551; 68788-7052; 69489-121; 70934-886; 71335-0682; 0591-3153; 71335-1237; 0591-5695; 0781-5386; 80425-0314; 17158-0900; 44657-0051; 65862-211; 65862-555; 73309-310; 13668-483; 50090-2339; 51655-753; 55289-201; 55700-415; 63629-9215; 67877-437; 67877-577; 68180-380; 68382-533; 69489-123; 57664-854; 59651-339; 63629-9213; 65862-209; 65862-885; 70518-2943; 71205-272; 0781-5385; 59651-338; 13668-485; 42546-774; 47781-544; 55289-202; 61919-845; 63629-9210; 64380-155; 67296-1181; 71335-0046; 71335-1045; 71403-102; 58623-0133; 65862-558; 13668-487; 57664-856; 63187-036; 65862-210; 67877-643; 67877-644; 68382-318; 68382-552; 70771-1427; 70842-160; 70934-673; 71335-1123; 0591-5694; 72143-221; 99207-463; 99207-465; 58159-085; 68225-074; 73402-112; 13668-482; 13668-486; 53002-2880; 55111-638; 63187-450; 63187-850; 64380-154; 65862-556; 67877-438; 68180-379; 68382-316; 68382-317; 70771-1157; 71205-511; 71335-0570; 72143-222; 0115-9935; 43063-736; 43353-105; 43353-172; 65862-883; 68071-5262; 68180-460; 70771-1138; 70771-1155; 70771-1428; 71205-086; 71403-101; 72162-1840; 99207-466; 47781-546; 57664-851; 59651-337; 60687-336; 63629-9208; 63629-9211; 63629-9212; 67877-578; 68382-535; 70518-1336; 70771-1156; 50909-9101; 51927-2197; 50090-0632; 57664-855; 63629-9209; 68788-8265; 70771-1167; 70771-1426; 0904-6888; 13668-484; 47781-545; 53002-2210; 58118-0484 |
| UNII |
0020414E5U
|
| Synonyms |
Minocycline | Minox 50 | Aknemin | Aknin-Mino | Aknin Mino | Aknosan | Mynocine | Apo-Minocycline | Apo Minocycline | Arestin | Blemix | Cyclomin | Cyclops | Dentomycin | Dynacin | Icht-Oral | Icht Oral | Klinomycin | Lederderm | Mestacine | Minakne | Mino-Wolff | Mino Wolff | Minocin | Minocin MR | Minoclir | Minocycline Hydrochloride | Hydrochloride, Minocycline | Minocycline Monohydrochloride | Monohydrochloride, Minocycline | Minocycline, (4R-(4 alpha,4a beta,5a beta,12a beta))-Isomer | Minolis | Minomycin | Minoplus | Minotab | Akamin | Akne-Puren | Akne Puren |
