Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoclopramide
Drug ID BADD_D01442
Description Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.[L8417] One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]
Indications and Usage Metoclopramide in the oral tablet form is used for symptomatic treatment of both acute and recurrent diabetic gastroparesis, in addition to the treatment of gastroesophageal reflux disease (GERD) in patients who have failed to respond to traditional therapy.[L8414] A nasal spray formulation is also indicated to treat adults with acute, recurrent diabetic gastroparesis.[L14381] In the intravenous injection form, it is indicated for the above conditions as well as for the prevention of vomiting that may follow emetogenic chemotherapy or nausea and vomiting after surgery. Intravenous metoclopramide facilitates intubation of the small bowel and stimulates gastric emptying and barium flow in patients who require radiological examination of the stomach or small intestine. In some cases, the delay of gastrointestinal emptying interferes with the radiographic visualization of the gastrointestinal tract, and metoclopramide is used to facilitate emptying in these cases, allowing for adequate diagnostic visualization.[L8417] Some off-label uses of metoclopramide include the management of radiation-induced nausea and vomiting, gastric bezoars, intractable hiccups, and migraine pain.[A184961,A184964,A184967,A40105]
Marketing Status approved; investigational
ATC Code A03FA01
DrugBank ID DB01233
KEGG ID D00726
MeSH ID D008787
PubChem ID 4168
TTD Drug ID D08VYV
NDC Product Code 49884-689; 51662-1367; 62559-296; 62559-295; 70518-0669; 71335-0362; 71335-0790; 0409-5255; 70518-1193; 71872-7076; 0615-8285; 50090-0132; 63629-2144; 49999-057; 60687-620; 0093-2204; 51079-886; 51079-888; 68788-7226; 51662-1288; 63187-235; 63629-8745; 0409-3414; 68788-7930; 0703-4502; 0093-2203; 51655-240; 55154-4383; 60687-631; 62559-190; 63629-1961; 63629-7967; 42291-596; 63187-404; 0615-7698; 43353-274
UNII L4YEB44I46
Synonyms Metoclopramide | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | Metaclopramide | Maxolon | Rimetin | Metoclopramide Hydrochloride | Hydrochloride, Metoclopramide | Metoclopramide Monohydrochloride | Monohydrochloride, Metoclopramide | Metoclopramide Monohydrochloride, Monohydrate | Primperan | Reglan | Cerucal | Metoclopramide Dihydrochloride | Dihydrochloride, Metoclopramide
Chemical Information
Molecular Formula C14H22ClN3O2
CAS Registry Number 364-62-5
SMILES CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Supraventricular tachycardia02.03.03.012--
Swollen tongue07.14.02.003; 10.01.05.015; 23.04.01.014---
Tachycardia02.03.02.0070.002705%-
Tachypnoea22.02.01.0140.000294%-
Tardive dyskinesia17.01.02.0120.261093%-
Tetanus11.02.02.007; 17.05.02.011---
Tic17.02.05.024; 19.11.04.0010.000529%-
Tongue disorder07.14.01.0020.000196%-
Tongue oedema07.14.02.007; 10.01.05.008; 23.04.01.0090.000294%-
Tongue paralysis07.14.02.012; 17.04.09.001---
Tonic convulsion17.12.03.0110.000392%-
Torticollis15.05.04.003; 17.01.03.0030.000686%-
Tremor17.01.06.0020.019428%
Trismus15.05.04.004; 17.01.03.0040.000921%
Unresponsive to stimuli17.02.05.031---
Urinary incontinence17.05.01.008; 20.02.02.010--
Urticaria10.01.06.001; 23.04.02.001--
Ventricular fibrillation02.03.04.008--
Ventricular tachycardia02.03.04.010--
Vision blurred06.02.06.007; 17.17.01.010--
Visual impairment06.02.10.0130.008175%-
Wheezing22.03.01.009--
Emotional distress19.04.02.0080.006469%-
Acute coronary syndrome02.02.02.015; 24.04.04.0110.000196%-
Haemodynamic instability24.03.02.0060.000196%-
Obsessive rumination19.06.05.006---
Pre-existing disease08.01.03.0590.001960%-
Gaze palsy06.05.02.014; 17.02.05.0440.000529%-
Hypoaesthesia oral07.05.05.003; 17.02.06.0210.000392%-
Major depression19.15.01.0030.000196%-
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ADReCS-Target
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