Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Methylphenidate
Drug ID BADD_D01431
Description Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve the following group of developmentally inappropriate symptoms associated with ADHD: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity. Long-acting formulations of psychostimulants such as methylphenidate, [DB01576], and [DB01255] are considered the most effective and widely used treatment for ADHD, and are considered first-line options for children, adolescents, and adults as recommended by CADDRA (Canadian ADHD Resource Alliance). [L6037] CADDRA recommends the use of methylphenidate due to long term studies, of over twenty years in duration, which show methylphenidate is safe and effective.
Indications and Usage Methylphenidate is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years of age and older and for the treatment of narcolepsy.
Marketing Status approved; investigational
ATC Code N06BA04
DrugBank ID DB00422
KEGG ID D04999
MeSH ID D008774
PubChem ID 4158
TTD Drug ID D02PPN
NDC Product Code 0781-2363; 0378-8263; 0574-2420; 0406-7654; 70165-200; 0378-8261; 68968-5552; 68968-5555; 70165-100; 0781-2362; 0781-2364; 0378-8262; 0574-2410; 0574-2430; 0574-2415; 68968-5553; 70165-300; 68968-5554; 0781-2361; 0378-8260
UNII 207ZZ9QZ49
Synonyms Methylphenidate | Metadate | Equasym | Methylin | Concerta | Phenidylate | Ritalin | Ritaline | Ritalin-SR | Ritalin SR | Tsentedrin | Centedrin | Daytrana | Methylphenidate Hydrochloride | Hydrochloride, Methylphenidate
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 113-45-1
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood pressure decreased13.14.03.002---
Blood pressure fluctuation24.06.01.002---
Blood pressure increased13.14.03.005---
Body temperature increased13.15.01.001---
Bone disorder15.02.04.004---
Bradycardia02.03.02.002---
Bronchitis11.01.09.001; 22.07.01.001--
Bruxism07.01.06.008; 19.11.03.0010.000201%-
Bundle branch block right02.03.01.0110.000164%-
Burning sensation08.01.09.029; 17.02.06.001---
Cardiac arrest02.03.04.001--
Cardiac failure acute02.05.01.0050.000041%-
Cardiac murmur13.14.01.001---
Cardiomegaly02.04.02.0010.000041%-
Cardiomyopathy02.04.01.0010.000247%-
Cardiovascular disorder02.11.01.010; 24.03.02.0090.000152%-
Cataplexy15.05.04.010; 17.15.01.003; 19.02.02.0030.000041%-
Catatonia19.11.01.001---
Cerebellar infarction17.08.01.013; 24.04.06.0070.000062%-
Cerebral arteritis17.08.02.004; 24.12.02.0020.000041%-
Cerebral artery occlusion17.08.01.028; 24.04.06.0200.000041%-
Cerebral haemorrhage17.08.01.003; 24.07.04.001---
Cerebral infarction17.08.01.004; 24.04.06.0020.000185%-
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Cerebrovascular disorder17.08.02.002; 24.03.05.002---
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.0020.000358%-
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.0030.001065%-
Chills08.01.09.001; 15.05.03.016--
Cholelithiasis09.03.01.0020.000082%-
Choreoathetosis17.01.01.0030.000062%-
The 3th Page    First    Pre   3 4 5 6 7    Next   Last    Total 23 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene