Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cataplexy
ADR ID BADD_A00808
ADR Hierarchy
19      Psychiatric disorders
19.02      Sleep disorders and disturbances
19.02.02      Narcolepsy and associated conditions
19.02.02.003      Cataplexy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.010      Cataplexy
17      Nervous system disorders
17.15      Sleep disturbances (incl subtypes)
17.15.01      Narcolepsy and hypersomnia
17.15.01.003      Cataplexy
Description A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396) [MeSH]
MedDRA Code 10007737
MeSH ID D002385
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cataplexy | Cataplexy aggravated | Tonelessness Syndrome | Syndrome, Tonelessness | Syndromes, Tonelessness | Tonelessness Syndromes | Cataleptic Attacks | Attack, Cataleptic | Attacks, Cataleptic | Cataleptic Attack | Henneberg Syndrome | Syndrome, Henneberg | Status Cataplexicus
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00511Clozapine--
BADD_D00734Duloxetine0.000053%
BADD_D01102Hydroxybutanoic acid--
BADD_D01243Lamotrigine0.000110%
BADD_D01431Methylphenidate0.000041%
BADD_D01465Miglustat0.018112%
BADD_D01484Modafinil0.001852%
BADD_D02047Sodium oxybate0.020494%
BADD_D02103Suvorexant0.000196%
BADD_D02563Lemborexant0.000666%
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