Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Metaxalone
Drug ID BADD_D01400
Description Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone is associated with few side effects and is available as a 800 mg scored tablet.
Indications and Usage For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.
Marketing Status approved
ATC Code Not Available
DrugBank ID DB00660
KEGG ID D00773
MeSH ID C011301
PubChem ID 15459
TTD Drug ID D0S5CH
NDC Product Code 50228-323; 50228-474; 55700-911; 61919-832; 64980-472; 67296-1577; 68001-004; 68001-485; 68084-135; 69097-998; 0527-1435; 80425-0131; 12666-0012; 42494-449; 50268-530; 50436-0449; 53746-553; 67296-0993; 70518-0818; 75945-070; 0115-1745; 60687-663; 68040-712; 71205-961; 71335-0958; 63187-490; 63629-2398; 71205-326; 80425-0084; 65977-0089; 42291-587; 51655-602; 67296-1275; 70518-0771; 70934-429; 71205-016; 71335-1320; 17511-104; 50056-1999; 45865-985; 55700-494; 60760-289; 61919-091; 68788-7675; 69306-100; 45865-942; 51655-792; 0276-0508; 67296-1778; 68071-2849; 0904-6831; 60760-093; 63629-8014; 68788-7018; 69306-311; 0591-2341; 71335-2066; 0185-0448; 51655-171; 71205-426; 71205-470; 72789-028; 72789-122; 76420-232; 10920-581; 63629-2097; 65162-553; 68788-7499; 70518-2275; 70934-286; 80425-0122; 47621-020; 52076-6231; 73680-0011; 50090-3650; 55111-650
UNII 1NMA9J598Y
Synonyms metaxalone | Skelaxin | AHR 438
Chemical Information
Molecular Formula C12H15NO3
CAS Registry Number 1665-48-1
SMILES CC1=CC(=CC(=C1)OCC2CNC(=O)O2)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Anaphylactic shock10.01.07.002; 24.06.02.004---
Anaphylactoid reaction10.01.07.003; 24.06.03.007---
Asthenia08.01.01.0010.000780%-
Ataxia08.01.02.004; 17.02.02.0010.000229%
Back pain15.03.04.0050.000780%
Cardiac arrest02.03.04.0010.000344%
Clonus17.02.05.0020.000229%-
Coma17.02.09.0010.000803%-
Completed suicide08.04.01.010; 19.12.01.0010.001262%-
Delirium19.13.02.0010.000459%
Depressed level of consciousness17.02.04.0020.000803%
Dermatitis23.03.04.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug hypersensitivity10.01.01.0010.006239%-
Drug ineffective08.06.01.0060.002340%-
Haemolytic anaemia01.06.03.002---
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.0040.000229%
Hyperreflexia17.02.01.0020.000459%-
Hypersensitivity10.01.03.0030.000780%
Hypertension24.08.02.0010.000459%
Hypotension24.06.03.0020.001262%
Insomnia17.15.03.002; 19.02.01.0020.001170%
Irritability08.01.03.011; 19.04.02.013--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Leukopenia01.02.02.001---
Metabolic acidosis14.01.01.0030.000573%-
Muscle rigidity15.05.04.001; 17.05.02.0050.000459%-
Mydriasis06.05.03.004; 17.02.11.0030.000459%-
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