Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levonorgestrel
Drug ID BADD_D01281
Description Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available.[L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Indications and Usage For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
Marketing Status Prescription; OTC; Discontinued
ATC Code G03AC03; G03AD01
DrugBank ID DB00367
KEGG ID D00950
MeSH ID D016912
PubChem ID 13109
TTD Drug ID D0BA9U
NDC Product Code 50419-424; 73302-911; 22552-0047; 43386-622; 45541-1244; 51660-723; 12866-1010; 50419-422; 63190-0660; 63190-0130; 45541-1174; 65129-2003; 50090-1141; 62756-720; 58602-721; 16714-809; 50419-423; 66499-0018; 69536-162; 69536-146; 40032-622; 71205-361; 57297-852; 0113-2003; 65089-0036; 68071-4247; 58602-712; 0536-1142; 68071-4294; 64122-605; 44132-004; 50090-3830; 68180-853; 69536-200; 51508-012; 69536-103; 58602-841; 59057-002; 53104-7669; 62756-718; 62756-723; 69953-515; 68180-852; 70700-164; 69536-133; 71205-120; 59057-001; 50102-211; 0023-5858; 69953-616; 63190-0850; 68071-4126; 44132-012
Synonyms Levonorgestrel | l-Norgestrel | l Norgestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)- | D-Norgestrel | D Norgestrel | Microval | duofem | Microlut | Mirena | Norgeston | Norplant-2 | Norplant 2 | Norplant2 | NorLevo | Norplant | Plan B | Vikela | Cerazet | Capronor
Chemical Information
Molecular Formula C21H28O2
CAS Registry Number 797-63-7
SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bruxism07.01.06.008; 19.11.03.001--Not Available
Burning sensation08.01.09.029; 17.02.06.001--Not Available
C-reactive protein increased13.09.01.007--Not Available
Calcinosis08.03.04.0020.002085%Not Available
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.001--Not Available
Cardiovascular disorder02.01.01.001; 24.03.02.009--Not Available
Carpal tunnel syndrome17.09.02.001--Not Available
Cataract06.06.01.001--
Cellulitis11.02.01.001; 23.09.01.001--Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebral infarction17.08.01.004; 24.04.06.002--Not Available
Cerebral thrombosis17.08.01.006; 24.01.04.0030.000544%Not Available
Cerebral venous thrombosis17.08.03.002; 24.01.04.0050.012507%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Cervical discharge21.06.01.0010.004169%Not Available
Cervical dysplasia21.06.01.0020.074000%Not Available
Cervical incompetence18.02.02.009; 21.06.01.0080.004169%Not Available
Cervical polyp16.04.05.001; 21.06.02.0040.016676%Not Available
Cervicitis11.01.10.004; 21.14.05.0010.013549%
Cervix carcinoma16.12.01.001; 21.06.02.0010.003806%Not Available
Cervix disorder21.06.01.0030.022930%Not Available
Chest discomfort02.02.02.009; 08.01.08.019; 22.02.08.001--Not Available
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.003--Not Available
Chills08.01.09.001; 15.05.03.016--
Chloasma18.08.02.002; 23.05.01.0010.007296%Not Available
Choking sensation19.01.02.002; 22.02.05.0020.003127%Not Available
Cholangitis09.02.01.002--Not Available
Cholecystitis acute09.03.01.003--Not Available
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