Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Levomilnacipran hydrochloride
Drug ID BADD_D01280
Description Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor. Chemically, levomilnacipran is the 1S,2R-enantiomer of milnacipran. FDA approved on July 25, 2013.
Indications and Usage Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor and is indicated for the treatment of major depressive disorder (MDD).
Marketing Status approved; investigational
ATC Code N06AX28
DrugBank ID DB08918
KEGG ID D10133
MeSH ID D000078862
PubChem ID 6917778
TTD Drug ID D02XOK
NDC Product Code 50370-0043; 0456-2221; 53069-1090; 0456-2202; 0456-2212; 0456-2220; 0456-2200; 0456-2281; 69766-018; 0456-2280; 0456-2213; 0456-2241; 53069-1100; 51604-1183; 0456-2240
UNII 371U2ZK31U
Synonyms Levomilnacipran | Fetzima | Levomilnacipran Hydrochloride
Chemical Information
Molecular Formula C15H23ClN2O
CAS Registry Number 101152-94-7
SMILES CCN(CC)C(=O)C1(CC1CN)C2=CC=CC=C2.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Aggression19.05.01.001---
Agitation17.02.05.012; 19.06.02.001--
Anger19.04.02.001---
Angina pectoris02.02.02.002; 24.04.04.002--
Angle closure glaucoma06.03.01.001---
Blood cholesterol increased13.12.01.002--
Blood pressure diastolic increased13.14.03.004---
Blood pressure increased13.14.03.005---
Blood pressure systolic increased13.14.03.006---
Bruxism07.01.06.008; 19.11.03.001---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Conjunctival haemorrhage06.07.01.001; 24.07.05.001---
Constipation07.02.02.001--
Dermatitis23.03.04.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dizziness postural02.11.04.008; 17.02.05.004; 24.06.02.008---
Dry eye06.08.02.001--
Dry skin23.03.03.001--
Ejaculation delayed21.03.01.001---
Ejaculation disorder21.03.01.002--
Ejaculation failure21.03.01.003---
Epididymitis11.01.19.005; 21.09.02.001---
Extrapyramidal disorder17.01.02.007--
Eye disorder06.08.03.001---
Flatulence07.01.04.002--
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemorrhagic disorder01.01.03.004; 24.07.01.021---
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