Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levobupivacaine
Drug ID BADD_D01269
Description Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Chirocaine. In particular, the specific levobupivacaine enantiomer is a worthwhile pursuit because it demonstrates less vasodilation and possesses a greater length of action in comparison to bupivacaine. It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine.Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children. When administered appropriately, the occurrence of adverse effects is not anticipated much if at all. In general, the majority of potential adverse effects are predominantly associated with inappropriate administration methods that may cause systemic exposure and/or toxicity associated with overexposure to an anesthetic. Regardless, allergic reactions may also occur - although only rarely.
Indications and Usage For the production of local or regional anesthesia for surgery and obstetrics, and for post-operative pain management
Marketing Status approved; investigational
ATC Code N01BB10
DrugBank ID DB01002
KEGG ID D08116
MeSH ID D000077554
PubChem ID 92253
TTD Drug ID D09QUQ
NDC Product Code 61876-0728
UNII A5H73K9U3W
Synonyms Levobupivacaine | Levobupivacaine Hydrochloride | Chirocaine
Chemical Information
Molecular Formula C18H28N2O
CAS Registry Number 27262-47-1
SMILES CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Electrocardiogram abnormal13.14.05.001---
Erythema23.03.06.001---
Extrasystoles02.03.02.003---
Feeling abnormal08.01.09.014---
Flatulence07.01.04.002--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Foetal distress syndrome18.03.02.003---
Gastrointestinal pain07.01.05.005--
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemorrhage in pregnancy18.02.01.003; 24.07.03.015---
Headache17.14.01.001--
Horner's syndrome06.09.04.002; 16.32.03.006; 17.05.01.004---
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023; 23.03.03.081---
Hypokinesia17.01.02.009---
Hypotension24.06.03.002--
Hypothermia08.05.01.003; 12.05.03.001--
Ileus07.13.01.001--
Injury12.01.08.004---
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.005--
Leukocytosis01.02.01.002--
Loss of consciousness17.02.04.004---
Miosis06.05.03.003; 17.02.11.002---
Monoplegia17.01.04.003---
Muscle contractions involuntary15.05.03.008; 17.05.03.001---
Muscle spasms15.05.03.004--
Nausea07.01.07.001--
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