Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Lansoprazole
Drug ID BADD_D01245
Description Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole.[A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) along with other pathologies caused by excessive acid secretion.[A177053]
Indications and Usage Lansoprazole is used to reduce gastric acid secretion and is approved for short term treatment of active gastric ulcers, active duodenal ulcers, erosive reflux oesophagitis, symptomatic gastroesophageal reflux disease, and non-steroidal anti-inflammatory drug (NSAID) induced gastric and duodenal ulcers. [A4892][A177065][FDA Label] It may be used in the maintenance and healing of several gastric conditions including duodenal ulcers, NSAID related gastric ulcers, and erosive esophagitis.[FDA Label] Lansoprazole prevents recurrence of gastric ulcers in patients who have a documented history of gastric ulcers who also use NSAIDs chronically. [FDA Label] Predictably, it is also useful in the management of hypersecretory conditions including Zollinger-Ellison syndrome. [FDA Label] Lansoprazole is effective at eradicating H. pylori when used in conjunction with amoxicillin and clarithromycin (triple therapy) or with amoxicillin alone (dual therapy). [FDA Label]
Marketing Status approved; investigational
ATC Code A02BC03
DrugBank ID DB00448
KEGG ID D00355
MeSH ID D064747
PubChem ID 3883
TTD Drug ID D06YYD
NDC Product Code 11532-1441; 49711-0110; 52932-0730; 53104-7526; 55111-044; 16714-185; 0113-0117; 49035-373; 50090-6154; 55111-739; 56062-283; 60687-123; 61919-655; 63629-2340; 0378-8030; 68382-543; 68382-544; 69842-755; 0536-1368; 55111-399; 65628-080; 0093-3008; 0113-0116; 41163-150; 41250-391; 62175-515; 63739-555; 63868-429; 68788-6390; 70000-0612; 71335-0043; 71335-9693; 80425-0148; 43598-109; 66332-1443; 16571-698; 36800-295; 43598-560; 45802-245; 50090-5180; 51079-121; 55111-398; 55154-0253; 55910-307; 0363-0037; 0363-1212; 64764-541; 65862-896; 67877-274; 68071-2734; 71335-1820; 71335-2078; 72189-062; 55154-4848; 61919-890; 63981-117; 0378-6981; 65841-770; 68391-117; 71335-0917; 72288-343; 82009-039; 51927-0064; 65372-1136; 16571-697; 21130-046; 30142-983; 46122-698; 51316-006; 55289-704; 68001-112; 68382-771; 70771-1132; 71335-0058; 71335-9680; 72189-279; 81522-001; 51552-1239; 51927-0262; 65977-0013; 71052-242; 75945-567; 11673-117; 11822-0016; 11822-0019; 16714-186; 0093-3009; 0093-7350; 31722-570; 0113-6117; 41250-117; 43598-161; 43598-561; 46122-107; 60760-544; 64764-046; 68071-2274; 68071-5119; 70000-0069; 71335-1521; 71335-9694; 80425-0174; 0378-3995; 38779-2289; 42765-023; 63850-3309; 64374-007; 65015-658; 66332-1442; 0113-6002; 0113-7116; 41520-816; 49035-411; 50090-6079; 0363-0739; 0378-8015; 65862-895; 68001-111; 68196-045; 71335-0575; 71335-1425; 16571-742; 0093-7351; 30142-192; 51407-324; 0363-1419; 64764-543; 65841-769; 68016-758; 68382-772; 69256-401; 69842-270; 70700-262; 70756-806; 70756-807; 70771-1133; 72288-301; 83324-001; 63415-0060; 11673-280; 11822-3374; 31722-571; 0113-7003; 41163-117; 45865-879; 49348-301; 56062-117; 60687-111; 62011-0168; 63187-152; 63629-4851; 63981-582; 69842-507; 79903-068; 11532-1440; 21130-564; 27241-019; 27241-020; 30142-288; 45802-878; 63187-510; 0363-4069; 63629-2341; 63629-2342; 64764-544; 0378-6982; 67877-275; 68788-7742; 70000-0508; 70677-0124; 0536-1324; 70700-263; 71335-9695; 72288-829; 72476-020; 0904-6662; 51927-0256; 52562-021; 59349-0015; 11822-0117; 21130-181; 30142-117; 0113-1114; 36800-117; 36800-392; 37808-755; 43598-883; 49035-739; 55910-117
UNII 0K5C5T2QPG
Synonyms Lansoprazole | Lansoprazol | 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl)methyl)sulfinyl)benzimidazole | Lansoprazoles | Ogastro | AG 1749 | AG-1749 | AG1749 | Agopton | Bamalite | Lansol | Lansoprazole Sodium | Sodium, Lansoprazole | Lanzor | Monolitum | Opiren | Prevacid | Pro Ulco | Promeco | Takepron | Ulpax | Zoton | Ogast | Prezal
Chemical Information
Molecular Formula C16H14F3N3O2S
CAS Registry Number 103577-45-3
SMILES CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Oedema peripheral02.05.04.007; 08.01.07.007; 14.05.06.011--
Oesophageal achalasia07.02.03.004---
Oesophageal candidiasis07.19.06.001; 11.03.03.008---
Oesophageal spasm07.02.04.004---
Oesophageal stenosis07.13.02.001--
Oesophageal ulcer07.04.05.002--
Oesophagitis07.08.05.0010.000199%
Oliguria20.01.03.0040.000298%-
Optic neuritis06.04.08.002; 10.02.01.097; 17.04.05.001---
Oral candidiasis07.05.07.001; 11.03.03.004---
Oral discomfort07.05.05.0010.000368%-
Oral pain07.05.05.034--
Oropharyngeal swelling07.05.04.002; 10.01.05.014; 22.04.05.005; 23.04.01.0130.000219%-
Osteoarthritis15.01.04.0010.000099%-
Osteoporosis14.04.04.002; 15.02.03.0020.000249%
Otitis media04.05.01.001; 11.01.05.004--
Pain08.01.08.004--
Pain in jaw15.02.01.003---
Palmar erythema23.03.06.0100.000099%-
Palpitations02.11.04.0120.001521%
Pancreatic carcinoma07.21.09.002; 16.13.10.0010.000298%-
Pancreatitis07.18.01.001--
Pancreatitis acute07.18.01.0020.000199%-
Pancytopenia01.03.03.0030.000547%-
Panic attack19.06.04.0010.000348%-
Panic disorder19.06.04.0020.000099%-
Paraesthesia17.02.06.005; 23.03.03.094--
Paranoia19.05.01.0050.000149%-
Parosmia17.04.04.002; 22.04.03.007---
Pelvic pain07.01.06.012; 20.02.03.007; 21.10.01.001--
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ADReCS-Target
Drug Name ADR Term Target
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