Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Iloperidone
Drug ID BADD_D01134
Description Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. On June 9, 2004, Titan Pharmaceuticals gave the Phase III development rights to Vanda Pharmaceuticals. FDA approved on May 9, 2009.
Indications and Usage Treatment of acute schizophrenia.
Marketing Status approved
ATC Code N05AX14
DrugBank ID DB04946
KEGG ID D02666
MeSH ID C081732
PubChem ID 71360
TTD Drug ID D0M8VE
NDC Product Code 46016-1332; 43068-102; 51672-4178; 51672-4213; 43068-101; 43068-108; 51672-4180; 50379-0006; 63285-755; 63285-756; 66499-0067; 51672-4182; 0378-0632; 0378-0633; 43068-104; 43068-106; 43068-110; 66499-0042; 51672-4183; 0378-0631; 66022-0115; 43068-901; 51672-4181; 0378-0636; 43068-112; 43068-902; 0378-0634; 0378-0635; 43068-903; 0378-0630; 43068-113; 51672-4179; 51672-4184
UNII VPO7KJ050N
Synonyms iloperidone | Fanapt | HP 873 | HP-873 | Zomaril
Chemical Information
Molecular Formula C24H27FN2O4
CAS Registry Number 133454-47-4
SMILES CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dehydration14.05.05.001--
Delirium19.13.02.001--
Delusion19.10.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.0070.001529%
Dry eye06.08.02.001--
Dry mouth07.06.01.0020.000889%
Dry throat07.06.01.005; 22.12.03.005---
Duodenal ulcer07.04.02.002--
Dyskinesia17.01.02.006--
Dyspnoea02.11.05.003; 22.02.01.004--
Dyspnoea exertional02.11.05.005; 22.02.01.005---
Dysuria20.02.02.002--
Ear disorder04.03.01.001---
Ejaculation failure21.03.01.003---
Endocrine disorder05.09.01.001---
Enuresis19.07.04.001; 20.02.02.003---
Epistaxis22.04.03.001; 24.07.01.005--
Extrapyramidal disorder17.01.02.0070.000131%
Eye disorder06.08.03.001---
Eye swelling06.08.03.003---
Eyelid oedema06.04.04.004; 10.01.05.001; 23.04.01.003---
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014---
Fluid retention14.05.06.002; 20.01.02.003---
Gait disturbance08.01.02.002; 15.03.05.013; 17.02.05.0160.000640%
Galactorrhoea05.03.04.002; 21.05.02.0020.000287%-
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.003--
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ADReCS-Target
Drug Name ADR Term Target
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