Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Halofantrine hydrochloride
Drug ID BADD_D01053
Description Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
Indications and Usage For treatment of Severe malaria
Marketing Status approved
ATC Code P01BX01
DrugBank ID DB01218
KEGG ID D02485
MeSH ID C023768
PubChem ID 37392
TTD Drug ID D07MVK
NDC Product Code 52286-4195
UNII H77DL0Y630
Synonyms halofantrine | halofantrine hydrochloride | 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl | WR 171,699 | WR-171,669 | WR-171699 | WR 171669 | Halfan
Chemical Information
Molecular Formula C26H31Cl3F3NO
CAS Registry Number 36167-63-2
SMILES CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Altered state of consciousness17.02.04.001; 19.07.01.003---
Anaphylactic shock10.01.07.002; 24.06.02.004---
Arrhythmia02.03.02.001---
Arthralgia15.01.02.001--
Asthenia08.01.01.001---
Back pain15.03.04.005--
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Chills08.01.09.001; 15.05.03.016--
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
Cough22.02.03.001--
Depressed level of consciousness17.02.04.002--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Disability26.01.01.003---
Discomfort08.01.08.003---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyspepsia07.01.02.001--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014---
Gastrointestinal pain07.01.05.005--
Haematocrit decreased13.01.05.001---
Haemolysis01.06.04.002--
Haemolytic anaemia01.06.03.002---
Headache17.14.01.001--
Hypertensive crisis24.08.01.001---
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