ADReCS

Pharmaceutical Information

Drug Name	Fluoxetine
Drug ID	BADD_D00932
Description	Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI).[A181673] It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies.[L7721]
Indications and Usage	Fluoxetine is indicated for both acute and maintenance treatment of major depressive disorder, obsessive compulsive disorder, and bulimia nervosa; however, it is only indicated for acute treatment of panic disorder independent of whether agoraphobia is present.[L7664] Fluoxetine may also be used in combination with olanzapine to treat depression related to Bipolar I Disorder, and treatment resistant depression.[L7664]
Marketing Status	approved; vet_approved
ATC Code	N06AB03
DrugBank ID	DB00472
KEGG ID	D00326
MeSH ID	D005473
PubChem ID	3386
TTD Drug ID	D0TR5X
NDC Product Code	0093-0807; 43063-839; 53002-2305; 61919-869; 62332-243; 71335-0924; 0615-8093; 0093-7198; 50090-3180; 50111-647; 50228-421; 59651-308; 68645-130; 0615-7625; 72241-009; 0904-5785; 0904-7195; 49884-468; 55111-150; 59651-324; 62332-242; 65862-306; 71209-041; 61919-885; 63304-632; 72241-008; 80426-044; 63187-233; 63629-8179; 70518-3752; 71335-0565; 80425-0313; 59651-309; 13668-443; 46708-273; 68645-131; 80426-045; 23155-028; 23155-030; 42291-398; 42571-388; 62332-024; 63187-089; 71335-1048; 0904-5784; 23155-029; 42291-396; 42571-389; 62332-022; 72162-1506; 72241-007; 16714-112; 16714-113; 42291-397; 42571-387; 43598-566; 46708-272; 50228-420; 58118-0645; 70518-1619; 71209-042; 13668-473; 50111-648; 55154-1341; 61919-100; 62332-023; 63629-2201; 71205-178; 71205-188; 71209-040; 42708-025; 46708-271; 53002-5016
UNII	01K63SUP8D
Synonyms	Fluoxetine \| Fluoxetin \| N-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine \| Lilly-110140 \| Lilly 110140 \| Lilly110140 \| Sarafem \| Fluoxetine Hydrochloride \| Prozac

Chemical Information

Molecular Formula	C17H18F3NO
CAS Registry Number	54910-89-3
SMILES	CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Atelectasis neonatal	18.04.09.004; 22.11.01.004	0.000059%		-
Blood hyposmosis	14.05.01.008	0.000049%		-
Breast cancer recurrent	16.10.01.009; 21.05.01.017	0.000039%		-
Carcinoid syndrome	05.08.02.005; 16.32.02.004	0.000108%		-
Cephalo-pelvic disproportion	18.07.02.009	0.000030%		-
Coeliac disease	07.17.01.008; 10.04.04.012; 14.02.01.007	0.000039%		-
Concomitant disease aggravated	08.01.03.063	0.000030%		-
Confabulation	19.10.03.009	0.000020%		-
Cyanosis neonatal	18.04.09.006; 22.11.02.003	0.000039%		-
Dissociative identity disorder	19.14.01.006	0.000059%		-
Drowning	08.04.01.014; 12.01.18.003	0.000020%		-
Excessive masturbation	19.08.03.007	0.000020%		-
Exhibitionism	19.08.06.001	0.000043%		-
Grandiosity	19.05.01.019	0.000020%		-
Impulsive behaviour	19.18.01.001	0.000118%		-
Large for dates baby	18.04.02.004	0.000089%		-
Macrosomia	08.01.03.073	0.000039%		-
Mitral valve prolapse	02.07.01.008	0.000059%		-
Mitral valve stenosis	02.07.01.009	0.000020%		-
Neonatal anoxia	18.04.15.004; 22.11.02.005	0.000020%		-
Neonatal asphyxia	18.04.15.005; 22.11.02.006	0.000039%		-
Neonatal respiratory acidosis	14.01.04.006; 18.04.09.008; 22.11.01.009	0.000039%		-
Neonatal respiratory arrest	18.04.17.001; 22.11.02.008	0.000020%		-
Neonatal respiratory depression	18.04.17.002; 22.11.02.009	0.000079%		-
Neonatal respiratory distress syndrome	18.04.10.003; 22.11.02.010	0.000207%		-
Normal newborn	18.08.06.001	0.000067%		-
Persecutory delusion	19.10.01.007	0.000059%		-
Placenta praevia	18.05.02.004	0.000030%		-
Placenta praevia haemorrhage	18.02.01.005; 24.07.03.026	0.000020%		-
Placental insufficiency	18.05.02.006; 24.04.12.002	0.000020%		-

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