Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ethambutol
Drug ID BADD_D00841
Description Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis.[L31743] Ethambutol was first described in the literature in 1961.[A229048] It was developed out of a need for therapies active against isoniazid resistant strains of _Mycobacterium tuberculosis_.[A229048] Ethambutol was granted FDA approval on 6 November 1967.[L31663]
Indications and Usage Ethambutol is indicated in combination with other anti-tuberculosis drugs in the treatment of pulmonary tuberculosis.[L31663] Ethambutol is commonly used in combination with [isoniazid], [rifampin], and [pyrazinamide].[L31743]
Marketing Status approved
ATC Code J04AK02
DrugBank ID DB00330
KEGG ID D07925
MeSH ID D004977
PubChem ID 14052
TTD Drug ID D08QME
NDC Product Code 60592-243
UNII 8G167061QZ
Synonyms Ethambutol | Dexambutol | Etibi | EMB-Fatol | EMB Fatol | Etambutol Llorente | Llorente, Etambutol | Ethambutol Hydrochloride | Hydrochloride, Ethambutol | Myambutol | Miambutol | EMB-Hefa | EMB Hefa
Chemical Information
Molecular Formula C10H24N2O2
CAS Registry Number 74-55-5
SMILES CCC(CO)NCCNC(CC)CO
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash maculo-papular23.03.13.0040.001540%
Refraction disorder06.02.04.004---
Sensory loss17.02.07.007---
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.0070.001027%
Thrombocytopenia01.08.01.002---
Tinnitus04.04.01.002; 17.04.07.004--
Toxic epidermal necrolysis10.01.01.006; 11.07.01.006; 12.03.01.015; 23.03.01.008--
Vision blurred06.02.06.007; 17.17.01.010--
Visual acuity reduced06.02.10.012; 17.17.01.011--
Visual field defect06.02.07.003; 17.17.01.001---
Visual impairment06.02.10.0130.002567%-
Vitamin K deficiency14.12.03.0050.001027%-
Vomiting07.01.07.0030.001540%
Musculoskeletal discomfort15.03.04.001---
Major depression19.15.01.0030.001027%-
Optic nerve disorder06.02.08.001; 17.04.05.004--
Decreased appetite08.01.09.028; 14.03.01.0050.001540%
Ill-defined disorder08.01.03.049---
Gastrointestinal tract irritation07.08.03.008---
Drug-induced liver injury09.01.07.023; 12.03.01.0440.001027%-
Drug reaction with eosinophilia and systemic symptoms10.01.01.021; 12.03.01.064; 23.03.05.0050.001540%-
Hepatic cytolysis09.01.07.0360.001540%-
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ADReCS-Target
Drug Name ADR Term Target
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