Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Premature labour18.07.01.0020.000082%-
Presyncope02.11.04.013; 17.02.05.009; 24.06.02.0100.000428%
Proctalgia07.03.02.0010.000082%
Productive cough22.02.03.0050.000387%
Pruritus23.03.12.001--
Pulmonary embolism22.06.02.001; 24.01.06.001---
Pulmonary fibrosis22.01.02.0060.000164%
Pulmonary haemorrhage22.12.01.009; 24.07.01.0160.000288%
Pulmonary hypertension22.06.01.001; 24.08.03.0020.001826%
Pulmonary oedema02.05.02.003; 22.01.03.0030.000658%
Pulmonary thrombosis22.06.02.003; 24.01.06.0020.000123%-
Pulmonary veno-occlusive disease22.06.03.003; 24.01.06.0080.000329%-
Pyrexia08.05.02.0030.002558%
Rash23.03.13.0010.003199%-
Rash erythematous23.03.13.0290.000543%-
Rash macular23.03.13.0030.000206%-
Rash papular23.03.13.0170.000263%-
Rash pruritic23.03.13.0300.000387%-
Raynaud's phenomenon24.04.03.0030.000082%-
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Rectal prolapse07.03.01.0050.000082%-
Renal disorder20.01.02.0020.000370%-
Renal failure20.01.03.0050.001069%-
Respiratory arrest22.02.01.0090.000288%-
Respiratory disorder22.02.07.0020.000164%-
Respiratory distress22.02.01.0120.000576%-
Respiratory failure14.01.04.003; 22.02.06.0020.000987%
Retching07.01.07.0020.000304%-
Retroperitoneal haemorrhage07.07.02.002; 12.01.17.018; 24.07.01.0170.000082%
Rhinitis11.01.13.004; 22.07.03.006--
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