Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute coronary syndrome02.02.02.015; 24.04.04.011---
Haemodynamic instability24.03.02.0060.000288%-
Ear discomfort04.03.01.0050.000181%-
Catheter site erythema08.02.02.003; 12.07.02.003; 23.03.06.0140.002936%-
Catheter site inflammation08.02.02.010; 12.07.02.0100.001250%-
Catheter site pain08.02.02.004; 12.07.02.0040.001735%-
Lymphatic disorder01.09.01.003---
Paranasal sinus discomfort22.12.03.0180.000362%-
Musculoskeletal discomfort15.03.04.0010.000082%-
Secretion discharge08.01.03.0190.000164%-
Infusion site pain08.02.05.014; 12.07.05.0020.000164%-
Infusion site swelling08.02.05.002; 12.07.05.0030.000082%-
Foetal death08.04.01.011; 18.01.02.0030.000082%
Haemorrhage24.07.01.0020.001110%-
Pulmonary mass22.02.07.0040.000082%-
Procedural complication12.02.05.005--
Major depression19.15.01.003---
Toxic skin eruption10.01.01.008; 12.03.01.073; 23.03.05.0030.000082%-
Vasodilation procedure25.03.01.001---
Thyroid mass05.02.01.0030.000222%-
Restless legs syndrome15.05.03.012; 17.02.07.0080.000181%-
Angiopathy24.03.02.007---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.0050.000304%
Adverse event08.06.01.0100.000551%-
Abdominal hernia07.16.06.0050.000164%-
Appetite disorder14.03.01.004; 19.09.01.0020.000123%-
Cardiac disorder02.11.01.0030.000617%-
Connective tissue disorder10.04.04.026; 15.06.01.006---
Feeding disorder14.03.02.003; 19.09.01.0030.000082%-
Embolism24.01.01.0090.000123%
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