Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dulaglutide
Drug ID BADD_D00733
Description Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM).[A236070] Dulaglutide was initially approved by the FDA in 2014, and in February 2020 was approved for use in patients with T2DM and multiple cardiovascular risk factors for the prevention of cardiovascular events. It is the first T2DM drug approved to reduce major adverse cardiovascular events (MACE) risk in primary and secondary prevention populations.[L34665]
Indications and Usage Dulaglutide is as an adjunct therapy to diet and exercise for glycemic control in adults with type 2 diabetes mellitus. Additionally, it is indicated to reduce the risk of major adverse cardiovascular events (MACE) in adult type 2 diabetes mellitus patients with cardiovascular disease or multiple cardiovascular risk factors.[L30380]
Marketing Status approved; investigational
ATC Code A10BJ05
DrugBank ID DB09045
KEGG ID D09889
MeSH ID C555680
PubChem ID Not Available
TTD Drug ID D03NAW
NDC Product Code 54568-003; 63419-0525; 62195-433; 0002-3182; 50090-3484; 0002-1434; 62195-434; 50090-3483; 50090-6456; 62381-1433; 0002-1402; 50090-5467; 0002-1433; 50090-6453; 62381-1434; 0002-1401; 0002-2236; 54568-001
UNII WTT295HSY5
Synonyms dulaglutide | LY 2189265 | LY-2189265 | LY2189265 | Trulicity
Chemical Information
Molecular Formula Not Available
CAS Registry Number 923950-08-7
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010---
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.004---
Amylase increased13.05.01.009--
Asthenia08.01.01.001---
Atrioventricular block first degree02.03.01.004--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dyspepsia07.01.02.001--
Eructation07.01.02.003--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Frequent bowel movements07.02.04.002---
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal disorder07.11.01.001---
Gastrointestinal pain07.01.05.005--
Heart rate increased13.14.04.002---
Hypoglycaemia05.06.03.001; 14.06.03.001--
Injection site reaction08.02.03.014; 12.07.03.015--
Lip swelling07.05.04.005; 10.01.05.005; 23.04.01.007---
Lipase increased13.05.01.003--
Malaise08.01.01.003--
Nausea07.01.07.001--
Retching07.01.07.002---
Sinus tachycardia02.03.03.010--
Systemic lupus erythematosus rash10.04.03.005; 15.06.02.005; 23.03.13.007---
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