Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Domperidone
Drug ID BADD_D00705
Description A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Indications and Usage For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
Marketing Status approved; investigational; vet_approved
ATC Code A03FA03
DrugBank ID DB01184
KEGG ID D01745; D07868
MeSH ID D004294
PubChem ID 3151
TTD Drug ID D0AV3G
NDC Product Code 66326-101
UNII 5587267Z69
Synonyms Domperidone | Domperidon | Domidon | Domperidon AL | Domperidon Hexal | Hexal, Domperidon | Domperidon Stada | Stada, Domperidon | Domperidon-TEVA | Domperidon TEVA | Domperidona Gamir | Gamir, Domperidona | Domperidone Maleate | Maleate, Domperidone | Domperidone Maleate (1:1) | Domperidone Monohydrochloride | Monohydrochloride, Domperidone | Gastrocure | Motilium | Nauzelin | Novo-Domperidone | Novo Domperidone | Nu-Domperidone | Nu Domperidone | PMS-Domperidone | PMS Domperidone | Péridys | R-33,812 | R33,812 | R-33812 | R33812 | Ratio-Domperidone | Ratio Domperidone | Apo-Domperidone | Apo Domperidone
Chemical Information
Molecular Formula C22H24ClN5O2
CAS Registry Number 57808-66-9
SMILES C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001---
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Amenorrhoea05.05.01.002; 21.01.02.001--
Anxiety19.06.02.002--
Arrhythmia02.03.02.001---
Asthenia08.01.01.001---
Back pain15.03.04.005--
Blood prolactin increased13.10.03.002---
Breast enlargement21.05.04.001---
Breast pain21.05.05.003--
Burning sensation08.01.09.029; 17.02.06.001---
Cardiac arrest02.03.04.001--
Chest discomfort02.02.02.009; 08.01.08.019; 22.12.02.002---
Chest pain02.02.02.011; 08.01.08.002; 22.12.02.003---
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Crying08.01.03.005; 12.02.11.001; 17.02.05.013; 19.04.02.002---
Depression19.15.01.001--
Dermatitis23.03.04.002---
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug withdrawal syndrome08.06.02.004; 19.07.06.013---
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dystonia17.01.03.001---
Dysuria20.02.02.002--
Extrapyramidal disorder17.01.02.007--
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