Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Disulfiram
Drug ID BADD_D00695
Description A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Indications and Usage For the treatment and management of chronic alcoholism
Marketing Status approved
ATC Code N07BB01; P03AA04
DrugBank ID DB00822
KEGG ID D00131
MeSH ID D004221
PubChem ID 3117
TTD Drug ID D0X5SD
NDC Product Code 42973-137; 71052-221; 42794-028; 0054-0357; 73309-150; 51927-3121; 62135-432; 64980-171; 0054-0356; 38779-1971; 65571-0005; 62135-431; 64980-172; 51927-0188; 72643-028; 47781-607; 60429-196
UNII TR3MLJ1UAI
Synonyms Disulfiram | Bis(diethylthiocarbamoyl) Disulfide | Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2 | Tetraethylthiuram Disulfide | Disulfide, Tetraethylthiuram | Antabus | Antabuse | Teturam | Dicupral | Esperal | Alcophobin | Anticol
Chemical Information
Molecular Formula C10H20N2S4
CAS Registry Number 97-77-8
SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Tenderness08.01.08.005---
Therapeutic response unexpected08.06.01.0010.003777%-
Toxic encephalopathy12.03.01.027; 17.13.01.0040.016995%-
Tremor17.01.06.0020.003777%
Vomiting07.01.07.0030.015862%
Mental status changes19.07.01.0010.003777%-
Acute coronary syndrome02.02.02.015; 24.04.04.0110.003777%-
Peripheral sensorimotor neuropathy17.09.03.009---
Hot flush08.01.03.027; 21.02.02.001; 24.03.01.0050.008309%
Mental disorder19.07.01.0020.003777%-
Erectile dysfunction19.08.04.001; 21.03.01.007--
Psychiatric symptom19.01.02.0010.077422%-
Psychotic disorder19.03.01.0020.018884%
Liver injury09.01.07.022; 12.01.17.0120.003777%-
Drug-induced liver injury09.01.07.023; 12.03.01.0440.009442%-
Alcohol interaction08.06.03.0030.011330%-
Wernicke's encephalopathy14.12.02.013; 17.13.01.0130.003777%-
Subendocardial ischaemia02.02.02.027; 24.04.04.0330.003777%-
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ADReCS-Target
Drug Name ADR Term Target
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