Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyclizine
Drug ID BADD_D00543
Description A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Indications and Usage For prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems).
Marketing Status approved
ATC Code R06AE03
DrugBank ID DB01176
KEGG ID D03621
MeSH ID D003501
PubChem ID 6726
TTD Drug ID D08HRJ
NDC Product Code Not Available
UNII QRW9FCR9P2
Synonyms Cyclizine | Marezine | Cyclizine Hydrochloride | Hydrochloride, Cyclizine | Cyclizine HCl | HCl, Cyclizine
Chemical Information
Molecular Formula C18H22N2
CAS Registry Number 82-92-8
SMILES CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001---
Altered state of consciousness17.02.04.001; 19.07.01.003---
Anaphylactic shock10.01.07.002; 24.06.02.004---
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Apnoea22.02.01.001--
Asthenia08.01.01.001---
Blister12.01.06.002; 23.03.01.001---
Bronchospasm10.01.03.012; 22.03.01.004--
Chills08.01.09.001; 15.05.03.016--
Chorea17.01.01.001---
Constipation07.02.02.001--
Depressed level of consciousness17.02.04.002--
Dermatitis bullous23.03.01.002--
Discomfort08.01.08.003---
Disorientation17.02.05.015; 19.13.01.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Drug eruption08.01.06.015; 10.01.01.005; 23.03.05.001---
Dyskinesia17.01.02.006--
Erythema23.03.06.001---
Eye disorder06.08.03.001---
Hallucinations, mixed19.10.04.008---
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001---
Hepatitis09.01.07.004---
Hepatitis cholestatic09.01.01.002---
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Injection site reaction08.02.03.014; 12.07.03.015--
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