Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Angle closure glaucoma06.03.01.001---
Anisocytosis01.07.02.0080.004280%-
Ankylosing spondylitis10.04.04.004; 15.01.09.0010.001223%-
Anticholinergic syndrome17.05.01.0010.004280%-
Antisocial behaviour19.05.01.010---
Antisocial personality disorder19.05.03.002---
Anxiety19.06.02.002--
Aortic aneurysm24.02.03.001---
Aortic valve incompetence02.07.03.0010.003669%-
Apathy19.04.04.002---
Aphasia17.02.03.001; 19.21.01.001--
Aplasia pure red cell01.03.03.001; 10.02.01.0030.003057%-
Apraxia17.02.03.002; 19.21.01.0020.002446%-
Areflexia17.02.01.001---
Arrhythmia02.03.02.001---
Arteriosclerosis24.04.02.0010.007949%-
Arteriosclerosis coronary artery02.02.01.011; 24.04.04.0120.009171%-
Arthralgia15.01.02.001--
Asphyxia12.01.08.011; 22.02.02.0010.011006%-
Aspiration22.02.07.0070.036686%
Asterixis09.01.03.004; 17.01.06.0010.003057%-
Asthenia08.01.01.001---
Asthma10.01.03.010; 22.03.01.0020.046591%-
Ataxia08.01.02.004; 17.02.02.001--
Atelectasis22.01.02.0010.008560%
Atonic urinary bladder17.05.01.010; 20.03.03.004---
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Atrioventricular block02.03.01.002---
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ADReCS-Target
Drug Name ADR Term Target
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