Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel
Drug ID BADD_D00504
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213]
Marketing Status approved
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D07729; D10823; D10824
MeSH ID D000077144
PubChem ID 60606
TTD Drug ID D0N0TZ
NDC Product Code 42543-714; 50090-4918; 52605-083; 16729-218; 0024-1171; 68788-8190; 72578-012; 65977-0037; 52605-082; 63187-362; 63629-4728; 70518-0400; 33342-060; 42543-713; 65162-414; 0093-7314; 16729-219; 61919-007; 67296-1840; 50090-2598; 50090-5781; 0024-1332; 61919-737; 70771-1062; 16714-052; 68071-2813; 68071-4138; 71335-0581
UNII A74586SNO7
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H16ClNO2S
CAS Registry Number 113665-84-2
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Scrotal swelling21.12.02.0050.000021%-
Seizure17.12.03.001--
Sense of oppression08.01.09.0200.000021%-
Sensory loss17.02.07.0070.000032%-
Serum sickness10.01.03.004; 12.02.08.004--
Shock24.06.02.0020.000214%-
Sinus bradycardia02.03.03.0090.000064%
Sinusitis11.01.13.005; 22.07.03.007--
Sjogren's syndrome06.08.02.011; 07.06.01.010; 10.04.04.009; 15.06.01.0150.000064%-
Skin disorder23.03.03.007---
Skin exfoliation23.03.07.0030.000143%-
Skin lesion23.03.03.0100.000075%-
Skin necrosis23.03.03.0110.000096%-
Skin reaction10.01.03.019; 23.03.03.0130.000137%-
Skin ulcer23.07.03.003; 24.04.03.0070.000128%
Sleep paralysis17.15.02.005; 19.02.02.0040.000032%-
Small intestinal obstruction07.13.06.0010.000032%
Speech disorder17.02.08.003; 19.19.02.002; 22.12.03.027---
Spinal cord compression17.10.01.0060.000225%
Spinal osteoarthritis15.01.04.0030.000032%-
Splenomegaly01.09.02.0010.000032%-
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Stomatitis07.05.06.005--
Stress19.06.02.004---
Stridor22.04.02.003--
Subarachnoid haemorrhage12.01.10.011; 17.08.01.010; 24.07.04.0040.000732%-
Sudden death02.03.04.013; 08.04.01.0030.000053%
Supraventricular extrasystoles02.03.03.0110.000032%-
Supraventricular tachycardia02.03.03.0120.000032%
Surgery25.01.02.003---
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ADReCS-Target
Drug Name ADR Term Target
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