Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clonidine hydrochloride
Drug ID BADD_D00503
Description Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Indications and Usage May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD).
Marketing Status Prescription; Discontinued
ATC Code C02AC01; N02CX02; S01EA04
DrugBank ID DB00575
KEGG ID D00604
MeSH ID D003000
PubChem ID 20179
TTD Drug ID D03SKR
NDC Product Code 29300-136; 53002-4940; 53002-4941; 49452-2147; 59212-658; 60760-057; 67296-1196; 70934-851; 50090-3151; 10135-708; 63187-419; 68180-606; 61919-718; 50090-2775; 43353-316; 50090-1909; 71034-001; 59746-668; 63629-1328; 42413-0053; 50090-5089; 60760-178; 71205-570; 66267-061; 0395-8132; 62332-054; 67457-218; 55700-802; 79572-009; 68071-4041; 68382-601; 29300-137; 68788-7685; 50090-5105; 52935-0051; 71335-1624; 61919-605; 50090-5103; 68001-237; 43063-924; 43063-925; 68382-602; 81371-7005; 70518-1283; 70518-3162; 67046-327; 43547-567; 46708-306; 10135-709; 62332-056; 53002-4140; 63629-2318; 60429-431; 46708-308; 63629-7765; 76420-066; 63629-7652; 55700-704; 68071-4545; 61919-268; 43063-817; 71610-449; 66267-062; 71335-0050; 71335-0539; 71335-0121; 61919-266; 29300-468; 42291-148; 70771-1193; 46708-844; 63629-2317; 70518-0481; 68001-239; 68071-4094; 58118-0072; 68788-7145; 45865-797; 70934-752; 70518-3276; 70518-3350; 53747-010; 68071-4661; 63629-2319; 0228-2128; 70518-0350; 68001-238; 0143-9723; 72789-091; 71335-1495; 27241-108; 70518-1811; 66267-464; 51662-1210; 70518-1962; 71205-588; 68071-2631; 50090-1908; 29300-135; 70934-793; 71335-0777; 71205-218; 52817-180; 50090-1910; 62991-1422; 70934-226; 68071-3016; 63629-2316; 0615-2574; 58657-648; 52817-182; 58657-647; 68981-029; 68071-2210; 51927-2379; 60687-462; 0228-2129; 43547-566; 71335-0922; 63629-2314; 68071-4721; 61919-267; 43547-435; 68788-8163; 55154-2577; 50090-4360; 70518-1959; 0228-2127; 63629-1208; 55154-2576; 63629-2753; 58657-649; 52817-181; 67296-0685; 0615-2572; 63629-2315; 53002-4141; 0615-8272; 0143-9724; 68788-8080; 70518-3295; 70771-1194; 0228-4241; 71335-0915; 10135-710; 50090-5577; 51655-339; 60687-124; 68071-4601; 46708-307; 70934-271; 43547-565; 10370-257; 70518-1000; 38779-0561; 60687-113; 70518-0898; 62332-055
Synonyms Clonidine | Klofenil | Clofenil | Chlophazolin | Clonidine Dihydrochloride | Dihydrochloride, Clonidine | Clonidine Hydrochloride | Hydrochloride, Clonidine | Clonidine Monohydrochloride | Monohydrochloride, Clonidine | Clonidine Monohydrobromide | Monohydrobromide, Clonidine | ST-155 | ST 155 | ST155 | Gemiton | Hemiton | Isoglaucon | Klofelin | Clofelin | Clopheline | M-5041T | M 5041T | M5041T | Catapres | Catapresan | Catapressan | Dixarit
Chemical Information
Molecular Formula C9H10Cl3N3
CAS Registry Number 4205-91-8
SMILES C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl.Cl
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Agitation17.02.05.012; 19.06.02.001--
Alcohol intolerance14.02.01.001--
Alopecia23.02.02.001--
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anxiety19.06.02.002--
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Atrioventricular block02.03.01.002--Not Available
Blepharitis06.04.04.001; 23.03.04.012--Not Available
Blood creatine phosphokinase13.04.01.009--Not Available
Blood glucose increased13.02.02.002--Not Available
Bradycardia02.03.02.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.003--Not Available
Conjunctival follicles06.06.02.002--Not Available
Conjunctival oedema06.04.01.001--Not Available
Conjunctivitis06.04.01.002; 11.01.06.012--
Constipation07.02.02.001--
Coordination abnormal17.02.02.004--Not Available
Corneal erosion06.06.03.003--Not Available
Corneal infiltrates06.08.01.002--Not Available
Delirium19.13.02.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis contact10.01.01.003; 12.03.01.040; 23.03.04.004--Not Available
Discomfort08.01.08.003--Not Available
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