Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Chloral hydrate
Drug ID BADD_D00428
Description A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication.
Indications and Usage Mainly used as a hypnotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
Marketing Status approved; illicit; investigational; vet_approved
ATC Code N05CC01
DrugBank ID DB01563
KEGG ID D00265
MeSH ID D002697
PubChem ID 2707
TTD Drug ID D02OAV
NDC Product Code 76003-0294; 51927-0122; 65319-1224; 38779-0641; 51552-0528; 51927-1002
UNII 418M5916WG
Synonyms Chloral Hydrate | Hydrate, Chloral | Noctec
Chemical Information
Molecular Formula C2H3Cl3O2
CAS Registry Number 302-17-0
SMILES C(C(Cl)(Cl)Cl)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001---
Ataxia08.01.02.004; 17.02.02.001--
Cardiac arrest02.03.04.001--
Completed suicide08.04.01.010; 19.12.01.001---
Depressed level of consciousness17.02.04.002--
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.002---
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Ear pain04.03.01.003--
Eczema23.03.04.006--
Erythema23.03.06.001---
Erythema multiforme10.01.03.015; 23.03.01.003--
Face oedema08.01.07.003; 10.01.05.002; 23.04.01.004--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Hallucination19.10.04.003--
Hangover08.01.09.018---
Hypotension24.06.03.002--
Insomnia17.15.03.002; 19.02.01.002--
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Pruritus23.03.12.001--
Purpura01.01.04.003; 23.06.01.004; 24.07.06.005--
Pyrexia08.05.02.003--
Rash23.03.13.001---
Rash erythematous23.03.13.029---
Rash maculo-papular23.03.13.004--
Rash scarlatiniform23.03.13.006---
Sedation17.02.04.005---
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