ADReCS

Pharmaceutical Information

Drug Name	Cefuroxime
Drug ID	BADD_D00407
Description	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Indications and Usage	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Marketing Status	approved
ATC Code	J01DC02; S01AA27
DrugBank ID	DB01112
KEGG ID	D00262
MeSH ID	D002444
PubChem ID	41375
TTD Drug ID	D0Y2IE
NDC Product Code	0143-9567; 0143-9569; 0143-9976; 0143-9568; 0143-9977; 0143-9979
UNII	O1R9FJ93ED
Synonyms	Cefuroxime \| Cephuroxime \| Zinacef \| Ketocef

Chemical Information

Molecular Formula	C16H16N4O8S
CAS Registry Number	55268-75-2
SMILES	CON=C(C1=CC=CO1)C(=O)NC2C3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Cough	22.02.03.001	0.001002%
Creatinine renal clearance decreased	13.13.01.013	-	-	-
Cutaneous vasculitis	10.02.02.003; 23.06.02.001; 24.12.04.008	0.000358%		-
Cyanosis	02.11.04.004; 22.02.02.007; 23.06.04.005; 24.03.01.007	0.000429%
Delirium	19.13.02.001	0.000286%
Depressed level of consciousness	17.02.04.002	0.000358%
Dermatitis	23.03.04.002	0.000143%		-
Dermatitis allergic	10.01.03.014; 23.03.04.003	0.001416%		-
Dermatitis bullous	23.03.01.002	0.000601%
Dermatitis diaper	21.10.01.016; 23.03.04.005	-	-	-
Dermatitis exfoliative	10.01.01.004; 23.03.07.001	0.000529%
Diarrhoea	07.02.01.001	-	-
Diarrhoea haemorrhagic	07.02.01.002; 24.07.02.004	0.000215%		-
Diplopia	06.02.06.002; 17.17.01.005	-	-	-
Disability	26.01.01.003	-	-	-
Dizziness	02.11.04.006; 17.02.05.003; 24.06.02.007	-	-
Drug eruption	08.01.06.015; 10.01.01.005; 23.03.05.001	0.001660%		-
Drug hypersensitivity	10.01.01.001	0.008828%		-
Drug interaction	08.06.03.001	0.000572%		-
Dyspepsia	07.01.02.001	-	-
Dyspnoea	02.11.05.003; 22.02.01.004	0.005594%
Dysuria	20.02.02.002	0.000143%
Ear pain	04.03.01.003	0.000358%
Electrolyte imbalance	14.05.01.002	0.000143%		-
Emphysema	22.01.02.002	0.000143%		-
Enterocolitis	07.08.03.003	0.000143%
Eosinophilia	01.02.04.001	0.000744%
Epilepsy	17.12.03.002	0.000215%		-
Epistaxis	22.04.03.001; 24.07.01.005	-	-
Erythema	23.03.06.001	0.003191%		-

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