Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ceftaroline fosamil
Drug ID BADD_D00398
Description Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia.
Indications and Usage Ceftaroline fosamil is indicated for the treatment of patients with the following infections caused by susceptible isolates of the designated microorganisms.
Marketing Status approved; investigational
ATC Code J01DI02
DrugBank ID DB06590
KEGG ID D08884
MeSH ID C515501
PubChem ID 9852981
TTD Drug ID Not Available
NDC Product Code 0456-0400; 0456-0600
UNII 7P6FQA5D21
Synonyms ceftaroline fosamil | Teflaro | TAK-599 | TAK599 | PPI-0903 | PPI0903
Chemical Information
Molecular Formula C22H21N8O8PS4
CAS Registry Number 229016-73-3
SMILES CCON=C(C1=NSC(=N1)NP(=O)(O)O)C(=O)NC2C3N(C2=O)C(=C(CS3)SC4=NC(=CS4)C5=CC=[N+](C= C5)C)C(=O)[O-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypervolaemia02.05.04.019; 14.05.06.0030.000049%-
Hypokalaemia14.05.03.002--
Immune system disorder10.02.01.001---
Leukopenia01.02.02.0010.000049%-
Nausea07.01.07.0010.000379%
Nephropathy toxic12.03.01.010; 20.05.03.0020.000107%-
Nervous system disorder17.02.10.001---
Neutropenia01.02.03.0040.000612%-
Pain08.01.08.004--
Pain in extremity15.03.04.0100.000165%
Palpitations02.11.04.012--
Pancytopenia01.03.03.0030.000097%-
Phlebitis12.02.01.002; 24.12.03.004--
Pruritus23.03.12.0010.000544%
Pyrexia08.05.02.0030.000097%
Rash23.03.13.0010.000782%-
Renal failure20.01.03.0050.000097%-
Respiratory failure14.01.04.003; 22.02.06.0020.000107%
Seizure17.12.03.0010.000049%
Skin disorder23.03.03.007---
Stevens-Johnson syndrome10.01.01.045; 11.07.01.005; 12.03.01.014; 23.03.01.0070.000049%
Swelling face08.01.03.100; 10.01.05.018; 23.04.01.018---
Thrombocytopenia01.08.01.0020.000131%-
Urethral disorder20.07.01.002---
Urinary tract disorder20.08.01.001---
Urticaria10.01.06.001; 23.04.02.0010.000190%
Vomiting07.01.07.0030.000379%
Mental status changes19.07.01.0010.000049%-
Peripheral swelling02.05.04.015; 08.01.03.0530.000107%-
Lymphatic disorder01.09.01.003---
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