Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Caspofungin acetate
Drug ID BADD_D00377
Description Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of the fungal cell wall.
Indications and Usage For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
Marketing Status approved
ATC Code J02AX04
DrugBank ID DB00520
KEGG ID D02501
MeSH ID D000077336
PubChem ID 6850808
TTD Drug ID D00ZCN
NDC Product Code 70860-107; 72266-106; 72843-434; 14474-037; 69806-0092; 63323-358; 70860-106; 72266-107; 25021-195; 72611-700; 52076-6230; 0006-3823; 72611-702; 72843-533; 69766-064; 68083-158; 0781-3423; 57884-0030; 68083-159; 0781-3421; 62227-022; 25021-194; 63323-356; 0006-3822
UNII VUW370O5QE
Synonyms Caspofungin | Cancidas | MK 0991 | MK-0991 | MK0991 | Caspofungin MSD | L 743,872 | L-743,872 | L743,872 | L-743872 | L743872 | L 743872 | Caspofungin Acetate
Chemical Information
Molecular Formula C56H96N10O19
CAS Registry Number 179463-17-3
SMILES CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O) C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 17.02.05.003; 24.06.02.007--
Dyspepsia07.01.02.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Epistaxis22.04.03.001; 24.07.01.005--
Erythema23.03.06.001---
Erythema multiforme10.01.03.015; 23.03.01.003--
Fatigue08.01.01.002--
Febrile neutropenia01.02.03.002; 08.05.02.004--
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Haematocrit decreased13.01.05.001---
Haematuria20.02.01.006; 21.10.01.018; 24.07.01.047--
Haemoglobin decreased13.01.05.003---
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic necrosis09.01.07.002--
Hepatomegaly09.01.05.001---
Hepatotoxicity09.01.07.009; 12.03.01.008---
Hyperbilirubinaemia01.06.04.003; 09.01.01.003; 14.11.01.010---
Hypercalcaemia05.04.01.002; 14.04.01.003--
Hyperglycaemia05.06.02.002; 14.06.02.002--
Hypertension24.08.02.001--
Hypervolaemia02.05.04.019; 14.05.06.003---
Hypokalaemia14.05.03.002--
Hypomagnesaemia14.04.02.001--
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Insomnia17.15.03.002; 19.02.01.002--
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.030---
Mucosal inflammation08.01.06.002---
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