Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carmustine
Drug ID BADD_D00371
Description A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Indications and Usage For the treatment of brain tumors, multiple myeloma, Hodgkin's disease and Non-Hodgkin's lymphomas.
Marketing Status approved; investigational
ATC Code L01AD01
DrugBank ID DB00262
KEGG ID D00254
MeSH ID D002330
PubChem ID 2578
TTD Drug ID D01OXI
NDC Product Code 54879-036; 43598-628; 70710-1525; 70860-223; 0781-3474; 50137-0686; 57821-002; 14593-823; 16729-545; 23155-790; 70121-1482; 76339-121; 50683-0017; 54893-0055; 68475-503; 57884-0032; 16729-548; 23155-649; 55718-139; 59651-168; 24338-050; 58621-002; 59981-034; 23155-261; 71288-126
UNII U68WG3173Y
Synonyms Carmustine | BCNU | N,N'-Bis(2-Chloroethyl)-N-Nitrosourea | FIVB | 1,3-Bis(2-Chloroethyl)-1-Nitrosourea | BiCNU | Nitrumon
Chemical Information
Molecular Formula C5H9Cl2N3O2
CAS Registry Number 154-93-8
SMILES C(CCl)NC(=O)N(CCCl)N=O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vision blurred06.02.06.007; 17.17.01.010--
Visual field defect06.02.07.003; 17.17.01.001---
Visual impairment06.02.10.013---
Vomiting07.01.07.003--
Wound dehiscence12.02.05.003--
Brain oedema12.01.10.010; 17.07.02.0030.003917%
Tumour haemorrhage16.32.03.008; 24.07.01.0280.000168%
Deep vein thrombosis24.01.02.0030.000168%-
Malignant neoplasm progression16.16.01.0050.000280%-
Wound12.01.08.009; 23.03.11.043---
Musculoskeletal discomfort15.03.04.001---
Cerebral haematoma17.08.01.014; 24.07.04.0060.000168%-
Transaminases increased13.03.04.036---
Haemorrhage24.07.01.0020.000112%-
Dysplasia08.03.04.007---
Gastrointestinal toxicity07.08.03.006; 12.03.01.019---
Cerebral vasoconstriction17.08.02.012; 24.04.06.0250.000112%-
Blood alkaline phosphatase increased13.04.02.004--
Brain neoplasm16.30.01.003; 17.20.01.003---
Connective tissue disorder10.04.04.026; 15.06.01.006---
Ocular toxicity06.11.01.006; 12.03.01.031---
Haematotoxicity01.05.01.007; 12.03.01.0250.000112%-
Malnutrition14.03.02.004---
Mental disorder19.07.01.002---
Decreased appetite08.01.09.028; 14.03.01.0050.000224%
Renal injury12.01.05.001; 20.01.03.015---
Disease progression08.01.03.038--
Neoplasm recurrence16.16.02.004---
Pulmonary toxicity12.03.01.013; 22.01.02.0070.000112%-
Venoocclusive disease24.03.02.016---
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ADReCS-Target
Drug Name ADR Term Target
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