Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cerebrospinal fluid leakage
ADR ID BADD_A00850
ADR Hierarchy
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.05      Neurological signs and symptoms NEC
17.02.05.001      Cerebrospinal fluid leakage
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.10      Cerebral injuries NEC
12.01.10.004      Cerebrospinal fluid leakage
Description A disorder characterized by loss of cerebrospinal fluid into the surrounding tissues. [CTCAE] Discharge of cerebrospinal fluid through a hole through the skull bone most commonly draining from the nose (CEREBROSPINAL FLUID RHINORRHEA) or the ear (CEREBROSPINAL FLUID OTORRHEA). [MeSH]
MedDRA Code 10008164
MeSH ID D065634; D002558; D002559
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Cerebrospinal fluid leakage | Cerebrospinal fluid otorrhea | Cerebrospinal fluid rhinorrhea | CSF leakage | Leakage of cerebrospinal fluid | Liquorrhea | Cerebrospinal fluid rhinorrhoea | Liquorrhoea | Cerebrospinal fluid otorrhoea | Subgaleal cerebrospinal fluid collection | Cerebrospinal Fluid Leak | Cerebrospinal Fluid Leaks | Fluid Leak, Cerebrospinal | Fluid Leaks, Cerebrospinal | Leak, Cerebrospinal Fluid | Leaks, Cerebrospinal Fluid | Cerebrospinal Fluid Leakage | Cerebrospinal Fluid Leakages | Fluid Leakage, Cerebrospinal | Fluid Leakages, Cerebrospinal | Leakage, Cerebrospinal Fluid | Leakages, Cerebrospinal Fluid | Spinal Cerebrospinal Fluid Leak | Cerebrospinal Fluid Drainage | Cerebrospinal Fluid Drainages | Drainage, Cerebrospinal Fluid | Drainages, Cerebrospinal Fluid | Fluid Drainage, Cerebrospinal | Fluid Drainages, Cerebrospinal | Cerebrospinal Fluid Leak, Spontaneous | Cerebrospinal Fluid Leakage, Spontaneous | Spinal Cerebrospinal Fluid Leak, Spontaneous | Cerebrospinal Fluid Drainage, Spontaneous | Cerebrospinal Fluid Leak, Post-Traumatic | Cerebrospinal Fluid Leak, Post Traumatic | Cerebrospinal Fluid Drainage, Traumatic | Spinal Cerebrospinal Fluid Leak, Traumatic | Cerebrospinal Fluid Leakage, Post-Traumatic | Cerebrospinal Fluid Leakage, Post Traumatic | Cerebrospinal Fluid Leakage, Traumatic | Spinal Cerebrospinal Fluid Leak, Post-Traumatic | Spinal Cerebrospinal Fluid Leak, Post Traumatic | Cerebrospinal Fluid Drainage, Post-Traumatic | Cerebrospinal Fluid Drainage, Post Traumatic | Cerebrospinal Fluid Leak, Traumatic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00100Ambrisentan0.000120%
BADD_D00209Baclofen0.003468%
BADD_D00305Bromocriptine mesylate--
BADD_D00329Cabergoline0.100893%
BADD_D00371Carmustine0.000392%
BADD_D00623Dexamethasone0.000291%
BADD_D00854Etoposide0.000112%
BADD_D01265Levetiracetam0.000119%
BADD_D01835Pregabalin0.000052%
BADD_D01864Propofol0.000179%
BADD_D02150Temozolomide0.000112%
BADD_D02272Triamcinolone acetonide0.000082%
BADD_D02412Octreotide--
BADD_D02464Fingolimod0.000362%
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