Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carisoprodol
Drug ID BADD_D00370
Description Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications [A176047]. This drug is available by itself in an oral tablet or combined with aspirin, or in a fixed-dose combination with both aspirin and codeine [FDA label, F4060, F4069]. In January 2012, this drug was classified as a Schedule IV substance under the controlled substances act in several US states due to alarming rates of abuse [A176062, A176077] despite having a low potential for abuse in addition to a low risk of dependence [L5074].
Indications and Usage For the relief of discomfort associated with acute, painful, musculoskeletal conditions.
Marketing Status Prescription; Discontinued
ATC Code M03BA02
DrugBank ID DB00395
KEGG ID D00768
MeSH ID D002328
PubChem ID 2576
TTD Drug ID D05PLH
NDC Product Code 70518-2800; 72789-019; 64980-380; 52286-0021; 50090-3232; 42543-700; 17337-0406; 50228-109; 76333-135; 63629-1168; 17381-080; 52536-682; 0037-2001; 0591-5513; 43353-102; 65862-158; 50090-5953; 68071-4610; 50090-5955; 62756-808; 71610-531; 72189-310; 77777-112; 50090-5214; 50090-4263; 71335-0693; 63187-786; 70518-3131; 63629-1167; 16571-780; 63629-8477; 71335-1203; 50090-4261; 55700-907; 50090-4746; 69584-111; 29033-207; 55700-954; 49452-1761; 29033-214; 55700-836; 60429-508; 0037-2250; 63629-1169; 55289-049; 70934-663; 60760-397; 71205-339; 63629-8478; 65862-260; 63629-8479; 71610-617; 63629-8202; 50090-5212; 65862-693; 58657-645; 60760-705; 55700-770; 16571-781; 50742-656; 66064-5001; 61919-878; 0143-1176; 63629-9144; 51525-5901; 52536-688; 45865-984; 63629-2416; 50090-3048; 71205-241; 71610-097; 51927-3169; 72789-016; 16714-510; 63629-9145; 50090-4744; 68071-5075; 43063-824; 71610-430; 70518-2618; 67296-1404; 64980-381; 72789-190; 72789-182; 72643-017; 63629-4707
Synonyms Carisoprodol | Isopropylmeprobamate | Isomeprobamate | Carisoprodate | Isobamate | Carisoma | Mio Relax | Soma | Vanadom | Soprodol | Somalgit
Chemical Information
Molecular Formula C12H24N2O4
CAS Registry Number 78-44-4
SMILES CCCC(C)(COC(=O)N)COC(=O)NC(C)C
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.0010.001440%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.000864%
Anaphylactoid reaction10.01.07.003; 24.06.03.0070.000150%Not Available
Ataxia08.01.02.004; 17.02.02.001--
Back pain15.03.04.005--
Cardiac arrest02.03.04.0010.001878%
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.001052%Not Available
Coma17.02.09.0010.000451%Not Available
Completed suicide08.04.01.010; 19.12.01.0010.004657%Not Available
Cyanosis02.01.02.002; 22.02.02.007; 24.03.01.0070.000864%
Death08.04.01.0010.000901%
Delusion19.10.01.0010.000864%
Depressed level of consciousness17.02.04.0020.000864%
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness02.01.02.004; 17.02.05.003; 24.06.02.007--
Drug abuse19.07.02.0100.001577%Not Available
Drug dependence19.07.02.0090.001728%Not Available
Drug hypersensitivity10.01.01.0010.004895%Not Available
Drug withdrawal syndrome08.06.02.004; 19.07.02.0110.002016%Not Available
Dyspepsia07.01.02.001--
Feeling abnormal08.01.09.0140.001152%Not Available
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Headache17.14.01.001--
Hiccups07.01.06.009; 22.02.04.002--
Hypersensitivity10.01.03.0030.000864%
Hypertension24.08.02.0010.000576%
Hypotension24.06.03.0020.000864%
Hypoxia22.02.02.0030.000864%
Insomnia17.15.03.002; 19.02.01.0020.000576%
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ADReCS-Target
Drug Name ADR Term Target
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