ADReCS

Pharmaceutical Information

Drug Name	Capecitabine
Drug ID	BADD_D00349
Description	Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Indications and Usage	For the treatment of patients with metastatic breast cancer resistant to both paclitaxel and an anthracycline-containing chemotherapy regimen. May also be used in combination with docetaxel for the treatment of metastatic breast cancer in patients who have failed to respond to, or recurred or relasped during or following anthracycline-containing chemotherapy. Capecitabine is used alone as an adjuvant therapy following the complete resection of primary tumor in patients with stage III colon cancer when monotherapy with fluroprymidine is preferred. The use or capecitabine in combination regimens for advanced gastric cancer is currently being investigated.
Marketing Status	Prescription
ATC Code	L01BC06
DrugBank ID	DB01101
KEGG ID	D01223
MeSH ID	D000069287
PubChem ID	60953
TTD Drug ID	D00HCQ
NDC Product Code	72205-007; 69097-948; 59923-722; 59651-204; 0378-2511; 55111-893; 55111-496; 0054-0272; 72205-006; 70756-816; 50268-154; 51407-095; 15308-0714; 16714-467; 62756-239; 67877-458; 64980-277; 55512-0015; 16729-072; 68001-487; 67877-459; 55111-497; 51079-510; 35369-0010; 54893-0002; 70756-815; 63482-099; 60687-149; 0004-1101; 62331-043; 72485-205; 53183-4009; 69539-019; 0004-1100; 65162-843; 16729-073; 72969-094; 62756-238; 16714-468; 68554-0033; 69097-949; 54245-7014; 72485-204; 62756-088; 0054-0271; 59651-205; 0093-7473; 72606-555; 76302-001; 69539-020; 65162-844; 53104-7618; 0378-2512; 51407-096; 81955-0001; 63759-0001; 49452-1713; 68001-488; 65129-1241; 64980-276; 0093-7474; 72606-554; 59923-721
Synonyms	Capecitabine \| N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine \| Xeloda

Chemical Information

Molecular Formula	C15H22FN3O6
CAS Registry Number	154361-50-9
SMILES	CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O
Chemical Structure

ADRs Induced by Drug

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Bronchitis	11.01.09.001; 22.07.01.001	-	-
Bronchopulmonary aspergillosis	11.03.01.002; 22.07.08.001	0.000208%		Not Available
Bronchospasm	10.01.03.012; 22.03.01.004	0.004263%
Bundle branch block left	02.03.01.007	0.001332%		Not Available
Burning sensation	08.01.09.029; 17.02.06.001	0.010923%		Not Available
C-reactive protein increased	13.09.01.007	-	-	Not Available
Cachexia	08.01.01.009; 14.03.02.001; 16.32.03.011	0.000139%		Not Available
Cardiac arrest	02.03.04.001	0.002780%
Cardiac failure	02.05.01.001	-	-
Cardiac failure acute	02.05.01.005	0.000799%		Not Available
Cardiac failure congestive	02.05.01.002	-	-	Not Available
Cardiac murmur	13.14.01.001	-	-	Not Available
Cardio-respiratory arrest	02.03.04.002; 22.02.06.007	-	-	Not Available
Cardiogenic shock	02.05.01.003; 24.06.02.006	0.003197%		Not Available
Cardiomyopathy	02.04.01.001	0.003730%		Not Available
Cataract	06.06.01.001	-	-
Cellulitis	11.02.01.001; 23.09.01.001	-	-	Not Available
Cerebellar ataxia	08.01.02.006; 17.02.02.013	0.001066%		Not Available
Cerebellar infarction	17.08.01.013; 24.04.06.007	0.000533%		Not Available
Cerebral atrophy	17.11.01.001	0.000139%		Not Available
Cerebral haemorrhage	17.08.01.003; 24.07.04.001	-	-	Not Available
Cerebral infarction	17.08.01.004; 24.04.06.002	-	-	Not Available
Cerebral ischaemia	17.08.01.005; 24.04.06.003	0.000417%
Cerebral venous thrombosis	17.08.03.002; 24.01.04.005	0.000347%		Not Available
Cerebrovascular accident	17.08.01.007; 24.03.05.001	-	-
Cheilitis	07.05.01.001; 23.03.03.025	0.001066%
Chest discomfort	02.02.02.009; 08.01.08.019; 22.02.08.001	0.006127%		Not Available
Chest pain	02.02.02.011; 08.01.08.002; 22.02.08.003	0.017317%		Not Available
Chills	08.01.09.001; 15.05.03.016	-	-
Choking	22.02.05.001	-	-	Not Available

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