Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardiac tamponade02.06.01.0010.003354%
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.003354%Not Available
Cardiogenic shock02.05.01.003; 24.06.02.0060.003850%Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder02.01.01.001; 24.03.02.0090.001225%Not Available
Catatonia19.11.01.001--Not Available
Cellulitis11.02.01.001; 23.09.01.001--Not Available
Cerebellar syndrome17.02.02.0020.003354%Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebral infarction17.08.01.004; 24.04.06.0020.003354%Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Cerebrovascular disorder17.08.02.002; 24.03.05.002--Not Available
Cervical incompetence18.02.02.009; 21.06.01.0080.003354%Not Available
Chest discomfort02.02.02.009; 08.01.08.019; 22.02.08.0010.004696%Not Available
Chest pain02.02.02.011; 08.01.08.002; 22.02.08.0030.021467%Not Available
Cheyne-Stokes respiration22.02.01.0240.002013%Not Available
Chills08.01.09.001; 15.05.03.016--
Cholestasis09.01.01.0010.003354%Not Available
Chromatopsia06.02.05.0010.002013%Not Available
Chromaturia20.02.01.0020.002683%
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Circulatory collapse24.06.02.0010.006708%Not Available
Coagulopathy01.01.02.0010.002683%Not Available
Cold sweat08.01.03.024; 23.02.03.0020.002013%Not Available
Colitis ischaemic07.08.01.004; 24.04.08.012--Not Available
Coma17.02.09.0010.002800%Not Available
Conduction disorder02.03.01.0080.002013%
Confusional state17.02.03.005; 19.13.01.0010.016100%
Congenital anomaly03.02.01.001--Not Available
Conjunctivitis06.04.01.002; 11.01.06.012--
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ADReCS-Target
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