Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).
Marketing Status Prescription; Discontinued
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Aortic dissection24.02.03.0020.001342%Not Available
Aortic valve incompetence02.07.03.0010.000525%Not Available
Apathy19.04.04.0020.002013%Not Available
Aphasia17.02.03.001; 19.21.01.0010.006038%
Arrhythmia02.03.02.0010.018113%Not Available
Arrhythmia supraventricular02.03.03.0010.001342%Not Available
Arterial thrombosis24.01.01.002--Not Available
Arteriospasm coronary02.02.02.005; 24.04.04.0050.002013%Not Available
Arthralgia15.01.02.001--
Arthropathy15.01.01.003--Not Available
Ascites02.05.04.002; 07.07.01.001; 09.01.05.0030.005367%
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.0010.028846%Not Available
Asthma10.01.03.010; 22.03.01.0020.002683%Not Available
Ataxia08.01.02.004; 17.02.02.0010.001342%
Atrial fibrillation02.03.03.0020.025492%
Atrial flutter02.03.03.0030.002013%
Atrial septal defect02.04.02.009; 03.07.02.0020.009392%Not Available
Atrioventricular block02.03.01.0020.023480%Not Available
Atrioventricular block complete02.03.01.0030.018113%
Atrioventricular block first degree02.03.01.0040.010734%
Atrioventricular block second degree02.03.01.0050.007379%
Auditory disorder04.02.03.002--Not Available
Back pain15.03.04.005--
Basal cell carcinoma16.03.02.001; 23.08.02.0010.008050%Not Available
Bladder pain20.02.02.001--Not Available
Blepharospasm06.05.01.001; 17.17.02.0010.001342%Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
Blood bilirubin increased13.03.01.0080.004696%
Blood cholesterol increased13.12.01.0020.002013%
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ADReCS-Target
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