Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Biperiden hydrochloride
Drug ID BADD_D00275
Description A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.
Indications and Usage For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.
Marketing Status approved; investigational
ATC Code N04AA02
DrugBank ID DB00810
KEGG ID D02246
MeSH ID D001712
PubChem ID 92151
TTD Drug ID D0B4TN
NDC Product Code Not Available
UNII K35N76CUHF
Synonyms Biperiden | Biperidene | alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol | Biperiden, 1S-(1 alpha,2 alpha(R*),4 alpha)-Isomer | Biperiden, 1R-(1 alpha,2 alpha(R*),4 alpha)-Isomer | Akineton | Biperiden Hydrochloride | Hydrochloride, Biperiden
Chemical Information
Molecular Formula C21H30ClNO
CAS Registry Number 1235-82-1
SMILES C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation17.02.05.012; 19.06.02.001--
Anticholinergic syndrome17.05.01.001---
Bradycardia02.03.02.002---
Chorea17.01.01.001---
Constipation07.02.02.001--
Disorientation17.02.05.015; 19.13.01.002---
Dry mouth07.06.01.002--
Euphoric mood19.04.02.006--
Orthostatic hypotension17.05.01.020; 24.06.03.004---
Rapid eye movements sleep abnormal17.15.04.001; 19.02.03.004---
Somnolence17.02.04.006; 19.02.05.003--
Urinary retention20.02.02.011--
Vision blurred06.02.06.007; 17.17.01.010--
Abnormal behaviour19.01.01.001---
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