Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Bicalutamide
Drug ID BADD_D00271
Description Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.
Indications and Usage For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Marketing Status Prescription; Discontinued
ATC Code L02BB03
DrugBank ID DB01128
KEGG ID D00961
MeSH ID C053541
PubChem ID 2375
TTD Drug ID D0V9BD
NDC Product Code 60429-177; 70518-2993; 51846-1028; 16714-816; 62559-680; 0904-6019; 16729-023; 43265-0705; 15308-0360; 54893-0001; 49711-1504; 65841-613; 43265-7195; 49711-1509; 71205-577; 68382-224; 47335-485; 63629-8308; 63759-0004; 62559-890; 53104-7664; 46014-1111; 58623-0068
Synonyms bicalutamide | 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide | Casodex | Cosudex | ICI-176334 | ICI 176334
Chemical Information
Molecular Formula C18H14F4N2O4S
CAS Registry Number 90357-06-5
SMILES CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.0010.012889%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Aspartate aminotransferase increased13.03.01.0060.035445%
Asthenia08.01.01.0010.112778%Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Atelectasis22.01.02.0010.006444%
Atrial fibrillation02.03.03.0020.035445%
Atrial flutter02.03.03.0030.016111%
Atrial tachycardia02.03.03.0040.006444%
Atrioventricular block02.03.01.0020.006444%Not Available
Atrioventricular block first degree02.03.01.0040.012889%
Atrioventricular block second degree02.03.01.0050.006444%
Atypical pneumonia11.01.09.012; 22.07.01.0100.001681%Not Available
Autonomic nervous system imbalance08.01.01.010; 17.05.01.011; 24.06.01.0050.006444%Not Available
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Benign prostatic hyperplasia21.04.02.0010.006444%Not Available
Bladder stenosis20.03.01.011--Not Available
Blister12.01.06.002; 23.03.01.001--Not Available
Blood bilirubin increased13.03.01.0080.009667%
Blood calcium decreased13.11.01.0020.009667%Not Available
Blood creatine phosphokinase increased13.04.01.0010.009667%
Blood creatinine increased13.13.01.0040.022556%
Blood glucose abnormal13.02.02.008--Not Available
Blood glucose increased13.02.02.0020.016111%Not Available
Blood lactate dehydrogenase increased13.04.02.0020.012889%
Blood potassium increased13.11.01.0110.006444%Not Available
Blood pressure decreased13.14.03.0020.009667%Not Available
Blood pressure increased13.14.03.005--Not Available
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