Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Azacitidine
Drug ID BADD_D00194
Description A pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
Indications and Usage For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.
Marketing Status approved; investigational
ATC Code L01BC07
DrugBank ID DB00928
KEGG ID D03021
MeSH ID D001374
PubChem ID 9444
TTD Drug ID D09FAZ
NDC Product Code 0781-9253; 14096-121; 81955-0012; 16729-306; 55150-393; 63323-771; 68001-527; 69097-368; 69097-805; 71288-153; 72485-201; 65129-1222; 68554-0104; 72606-558; 53183-4011; 43598-678; 59572-102; 51916-350; 83137-0006; 16714-927; 43817-906; 59572-730; 68001-504; 71288-115; 63660-0010; 0781-3253; 42385-312; 66529-0013; 54893-0029; 82920-015; 68001-313; 42385-719; 43598-305; 16714-578; 51991-797; 64679-096; 70121-1237; 63592-1800; 0143-9606; 43598-143; 43598-465; 59572-740
UNII M801H13NRU
Synonyms Azacitidine | 5-Azacytidine | 5 Azacytidine | Azacytidine | Vidaza | NSC-102816 | NSC 102816 | NSC102816
Chemical Information
Molecular Formula C8H12N4O5
CAS Registry Number 320-67-2
SMILES C1=NC(=NC(=O)N1C2C(C(C(O2)CO)O)O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vomiting07.01.07.0030.008395%
Weight decreased13.15.01.005--
Wheezing22.03.01.009--
Musculoskeletal disorder15.03.05.0250.000392%-
Hypoacusis04.02.01.0060.000336%
Peripheral swelling02.05.04.015; 08.01.03.053---
Weight fluctuation14.03.02.0020.000112%-
Neutropenic sepsis01.02.03.007; 11.01.11.006---
General physical health deterioration08.01.03.0180.003638%-
Anal haemorrhage07.12.03.004; 24.07.02.0290.000168%
Upper respiratory tract inflammation22.12.03.0340.000224%-
Left ventricular dysfunction02.04.02.0110.000168%
Shock haemorrhagic14.05.05.003; 24.06.02.0140.000168%-
Cardiac death02.03.04.015; 08.04.01.007---
Intervertebral disc protrusion15.10.01.0040.000112%-
Subileus07.13.01.0040.000224%-
Abscess limb11.01.08.014; 15.03.05.001---
Contusion12.01.06.001; 15.03.05.007; 23.03.11.002; 24.07.06.001--
Musculoskeletal chest pain15.03.04.012; 22.09.01.001--
Lower gastrointestinal haemorrhage07.12.03.011; 24.07.02.0300.000336%
Staphylococcal bacteraemia11.02.05.001---
Post procedural haemorrhage12.02.05.004; 24.07.01.014--
Lacunar infarction17.08.01.016; 24.04.06.0090.000112%-
Cardiopulmonary failure02.05.01.004; 22.02.06.0040.000336%-
Catheter site haemorrhage08.02.02.002; 12.07.02.002; 24.07.01.003---
Systemic inflammatory response syndrome08.01.05.005; 10.02.01.008; 24.06.03.0080.000168%-
Malignant neoplasm progression16.16.01.005---
Injection site discolouration08.02.03.038; 12.07.03.038; 23.03.03.046---
Acute coronary syndrome02.02.02.015; 24.04.04.0110.000280%-
Skin induration23.03.03.020--
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ADReCS-Target
Drug Name ADR Term Target
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