Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. It has also been used to lower the risk of developing venous thrombosis post-orthopedic surgical procedures.
Marketing Status Prescription
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 65129-1344; 55111-980; 50193-0893; 63629-8432; 16436-0113; 70366-001; 46708-908; 52048-0420; 63850-8085; 42816-0893; 14445-150; 59651-051; 53747-062; 65015-897; 55154-0613; 66174-0091; 76397-007; 75945-060; 24196-190; 15308-1221; 12783-0894; 66651-921; 63415-0520; 70518-1861; 66039-925; 65372-1196; 55154-0612; 12783-0893; 69989-0006; 76397-010; 42765-025; 76072-1017; 14501-0089; 67835-0015; 69037-0023; 50090-1437; 0003-0894; 58623-0137; 0003-3764; 42816-0894; 67296-1673; 58032-2028; 50090-1436; 65727-081; 14445-014; 63629-7747; 14445-149
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Body mass index decreased13.15.01.0250.000265%Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.002517%Not Available
Bone pain15.02.01.001--
Bradycardia02.03.02.002--Not Available
Brain compression17.07.02.0050.000530%Not Available
Brain herniation12.01.10.001; 17.11.01.0020.000484%Not Available
Brain stem haemorrhage17.08.01.031; 24.07.04.0150.000622%Not Available
Brain stem infarction17.08.01.024; 24.04.06.0140.000662%Not Available
Breast cancer16.10.01.001; 21.05.01.003--Not Available
Breast mass21.05.04.002--Not Available
Bronchial obstruction22.03.01.0130.000265%
Bronchiolitis11.05.04.008; 22.03.02.0040.000265%Not Available
Bronchitis11.01.09.001; 22.07.01.001--
Bronchospasm10.01.03.012; 22.03.01.004--
Burning sensation08.01.09.029; 17.02.06.001--Not Available
C-reactive protein increased13.09.01.007--Not Available
Cachexia08.01.01.009; 14.03.02.001; 16.32.03.011--Not Available
Calculus bladder20.04.02.0020.000795%Not Available
Calculus urinary20.04.02.0010.000265%Not Available
Cardiac amyloidosis02.04.02.010; 10.02.05.0020.000104%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.005944%
Cardiac failure acute02.05.01.0050.000207%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac tamponade02.06.01.0010.008479%
Cardio-respiratory arrest02.03.04.002; 22.02.06.007--Not Available
Cardiogenic shock02.05.01.003; 24.06.02.006--Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder02.01.01.001; 24.03.02.009--Not Available
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