Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amiodarone
Drug ID BADD_D00115
Description Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings.[A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use should be reserved for its approved indications, according to prescribing information.[L3561,L11265,L11286]
Indications and Usage Intravenously, for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and hemodynamically unstable ventricular tachycardia in patients refractory to other therapy. Orally, for the treatment of life-threatening recurrent ventricular arrhythmias such as recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia.
Marketing Status Prescription; Discontinued
ATC Code C01BD01
DrugBank ID DB01118
KEGG ID D02910
MeSH ID D000638
PubChem ID 2157
TTD Drug ID D0L5WM
NDC Product Code Not Available
Synonyms Amiodarone | Amiodarona | Amiodarone Hydrochloride | Hydrochloride, Amiodarone | Amiohexal | Aratac | Tachydaron | Corbionax | Cordarone | Amiodarex | Trangorex | Kordaron | Cordarex | L-3428 | L 3428 | L3428 | Ortacrone | Rytmarone | SKF 33134-A | SKF 33134 A | SKF 33134A | Amiobeta | Braxan
Chemical Information
Molecular Formula C25H29I2NO3
CAS Registry Number 1951-25-3
SMILES CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Apnoea22.02.01.0010.000595%
Arrhythmia02.03.02.0010.002976%Not Available
Arthralgia15.01.02.001--
Ascites02.05.04.002; 07.07.01.001; 09.01.05.0030.001191%
Aspartate aminotransferase increased13.03.01.0060.001191%
Asthenia08.01.01.0010.058930%Not Available
Asthma10.01.03.010; 22.03.01.0020.000893%Not Available
Ataxia08.01.02.004; 17.02.02.0010.002083%
Atrial fibrillation02.03.03.0020.009226%
Atrial flutter02.03.03.0030.002679%
Atrial tachycardia02.03.03.0040.001488%
Atrioventricular block02.03.01.0020.001191%Not Available
Atrioventricular block complete02.03.01.0030.001786%
Atrioventricular block first degree02.03.01.0040.000595%
Atrioventricular block second degree02.03.01.0050.000595%
Atypical pneumonia11.01.09.012; 22.07.01.0100.000595%Not Available
Azotaemia20.01.01.0010.000595%Not Available
Back pain15.03.04.005--
Basedow's disease05.02.02.003; 06.09.04.003; 10.04.08.0040.001488%Not Available
Benign intracranial hypertension17.07.02.001--Not Available
Blindness06.02.02.001; 17.17.01.0030.012578%Not Available
Blindness unilateral06.02.02.009; 17.17.01.0160.001488%Not Available
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.0040.001786%
Blood glucose increased13.02.02.002--Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood thyroid stimulating hormone decreased13.10.03.0110.000893%Not Available
Blood thyroid stimulating hormone increased13.10.03.0060.001786%
Body temperature increased13.15.01.001--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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