ADReCS

Pharmaceutical Information

Drug Name	Allopurinol
Drug ID	BADD_D00076
Description	Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints [A175942]. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals [A175942]. Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout [A36705]. It was initially approved by the FDA in 1966 [L5674] and is now formulated by several manufacturers [L5677].
Indications and Usage	For the treatment of hyperuricemia associated with primary or secondary gout. Also indicated for the treatment of primary or secondary uric acid nephropathy, with or without the symptoms of gout, as well as chemotherapy-induced hyperuricemia and recurrent renal calculi.
Marketing Status	Prescription; Discontinued
ATC Code	M04AA01
DrugBank ID	DB00437
KEGG ID	D00224
MeSH ID	D000493
PubChem ID	135401907
TTD Drug ID	D04KYY
NDC Product Code	50268-063; 49711-0113; 16714-041; 0603-2116; 14445-001; 69967-008; 55700-879; 50090-4662; 23155-694; 53489-156; 0591-5544; 0904-7041; 0378-0181; 55700-935; 66267-665; 61919-748; 50090-5194; 67457-187; 51079-206; 63739-796; 43063-976; 68083-380; 23155-693; 70518-1678; 71335-0112; 17351-0041; 55700-540; 67296-1265; 71610-253; 63629-2113; 51079-205; 50268-064; 29300-350; 68071-2660; 70934-072; 55700-947; 55154-5534; 50090-0044; 70934-389; 61919-471; 55111-730; 68071-1805; 71610-197; 70518-3289; 70710-1210; 63629-1781; 58118-1156; 67296-1314; 49452-0008; 70518-1806; 65015-606; 16729-135; 0904-6571; 63552-151; 70771-1127; 55154-2338; 62584-988; 70199-016; 70710-1209; 43353-088; 55154-7892; 16729-134; 0615-8385; 0591-5543; 68108-0212; 71205-208; 63629-8020; 43063-975; 71335-0467; 70771-1126; 68071-2616; 63187-240; 53002-4821; 36974-0018; 50090-2544; 69967-009; 70934-504; 63629-7908; 0615-8321; 51927-0070; 71610-064; 63629-2111; 50090-5168; 71610-194; 60760-134; 53002-4820; 65219-380; 70934-295; 65977-0124; 43063-793; 70199-015; 67457-978; 71610-231; 67544-736; 50090-3760; 43063-079; 71205-377; 62584-713; 71205-049; 50090-4663; 63629-1675; 63552-150; 0378-0137; 16714-042; 16714-577; 55154-7981; 16714-576; 43063-935; 29300-349; 70934-209; 70518-0451; 55289-010; 43353-186; 0603-2115; 55154-5454; 43063-774; 71335-1656; 55111-729; 60760-139; 0904-6572; 63629-2112; 70934-681; 43063-934; 50090-3758; 63739-410; 57451-1166; 60429-180; 66064-2100; 51927-1915; 66267-224; 68788-7542; 53489-157; 63187-463; 70518-1573; 68788-7383
Synonyms	Allopurinol \| Uribenz \| Allopurin \| Allorin \| Allpargin \| Allural \| Pan Quimica \| Apulonga \| Apurin \| Atisuril \| Bleminol \| Caplenal \| Capurate \| Cellidrin \| Embarin \| Suspendol \| Foligan \| Hamarin \| Lopurin \| Lysuron \| Jenapurinol \| Milurit \| Milurite \| Novopurol \| Uripurinol \| Urosin \| Urtias \| Xanthomax \| Uridocid \| Xanturic \| Zygout \| Zyloprim \| Zyloric \| Pureduct \| Purinol \| Progout \| Remid \| Rimapurinol \| Roucol \| Tipuric \| Allohexal \| Allohexan \| Alloprin

Chemical Information

Molecular Formula	C5H4N4O
CAS Registry Number	315-30-0
SMILES	C1=NNC2=C1C(=O)NC=N2
Chemical Structure

ADRs Induced by Drug

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Pulmonary artery stenosis	22.06.03.006; 24.04.09.011	0.000132%		Not Available
Symblepharon	06.06.02.012	0.000395%		Not Available
Trichiasis	06.06.04.023; 23.02.06.011	0.000329%		Not Available
Uraemic encephalopathy	14.10.01.009; 17.13.01.012; 20.01.01.011	0.000132%		Not Available
Rheumatoid vasculitis	10.04.06.008; 15.01.03.006; 24.05.02.023	0.000329%		Not Available
Anti-neutrophil cytoplasmic antibody positive vasculitis	10.02.02.023; 24.05.02.016	0.000461%		Not Available
Lip erosion	07.05.01.016	0.000264%		Not Available
Necrotising ulcerative gingivostomatitis	07.05.07.018; 11.02.29.001	0.000103%		Not Available
General physical condition abnormal	13.15.01.040	0.000132%		Not Available
Human herpes virus 6 serology positive	13.08.03.025	0.000132%		Not Available
Age-related macular degeneration	06.09.03.018	0.000132%		Not Available
Stress cardiomyopathy	02.04.01.012; 24.04.04.026	0.000132%		Not Available
Human herpesvirus 8 infection	10.03.03.008; 11.05.02.033	0.000132%		Not Available
Left atrial dilatation	02.04.02.025	0.000132%		Not Available
Skin plaque	23.03.03.044	0.000198%		Not Available
Ocular pemphigoid	06.04.05.030; 10.04.04.015; 23.03.01.030	0.000198%		Not Available
HLA marker study positive	13.22.01.011	0.000527%		Not Available
Interstitial granulomatous dermatitis	10.04.02.016; 23.03.15.007	0.000132%		Not Available
Overlap syndrome	10.04.04.016; 15.06.01.016; 23.03.02.018	0.000395%		Not Available
Roseolovirus test positive	13.08.03.032	0.000132%		Not Available
Prerenal failure	20.01.03.022; 24.06.02.025	0.000198%		Not Available
Fulminant type 1 diabetes mellitus	05.06.01.013; 14.06.01.013	0.000329%		Not Available
HLA-B*5801 assay positive	13.22.01.012	0.000329%		Not Available
Autoimmune hypothyroidism	05.02.03.005; 10.04.08.009	0.000264%		Not Available

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