Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Alendronic acid
Drug ID BADD_D00066
Description Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Indications and Usage Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Marketing Status approved
ATC Code M05BA04
DrugBank ID DB00630
KEGG ID D07119
MeSH ID D019386
PubChem ID 2088
TTD Drug ID D09KLR
NDC Product Code Not Available
UNII X1J18R4W8P
Synonyms Alendronate | 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate | Aminohydroxybutane Bisphosphonate | MK-217 | MK 217 | MK217 | Alendronate Monosodium Salt, Trihydrate | Alendronate Sodium | Fosamax
Chemical Information
Molecular Formula C4H13NO7P2
CAS Registry Number 66376-36-1
SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Basal cell carcinoma16.03.02.001; 23.08.02.0010.000704%-
Benign breast neoplasm16.14.01.005; 21.05.01.0090.000154%-
Benign neoplasm of skin16.26.01.006; 23.10.01.0060.000110%-
Benign prostatic hyperplasia21.04.02.0010.000154%-
Bile duct stone09.02.02.0030.000066%-
Bladder dilatation20.03.01.0070.000044%-
Bladder discomfort20.02.02.0190.000097%-
Bladder neoplasm16.08.03.002; 20.03.04.0020.000088%-
Bladder pain20.02.02.0010.000044%-
Blepharitis06.04.04.001; 23.03.04.0120.000198%-
Blindness06.02.10.003; 17.17.01.0030.000242%-
Blindness unilateral06.02.10.007; 17.17.01.0160.000066%-
Blister12.01.06.002; 23.03.01.0010.000374%-
Body temperature increased13.15.01.001---
Bone development abnormal15.02.04.0030.000066%-
Bone disorder15.02.04.0040.009611%-
Bone neoplasm15.09.02.001; 16.29.01.0010.000044%-
Bone pain15.02.01.0010.002060%
Bradycardia02.03.02.0020.000440%-
Breast cancer16.10.01.001; 21.05.01.0030.001123%-
Breast cyst16.14.01.004; 21.05.01.0060.000154%-
Breast disorder female21.05.04.0070.000044%-
Breast enlargement21.05.04.0010.000044%-
Breast hyperplasia21.05.01.0070.000044%-
Breast mass21.05.04.0020.000572%-
Breast pain21.05.05.0030.000088%
Breath odour07.01.06.0020.000044%-
Bronchiectasis22.03.02.0050.000044%-
Bronchitis chronic22.03.01.0190.000198%-
Bronchospasm10.01.03.012; 22.03.01.0040.000132%
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