Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Acetazolamide
Drug ID BADD_D00025
Description One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Indications and Usage For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
Marketing Status Prescription; Discontinued
ATC Code S01EC01
DrugBank ID DB00819
KEGG ID D00218
MeSH ID D000086
PubChem ID 1986
TTD Drug ID D0E1SW
NDC Product Code 0143-9503; 0904-6663; 42291-090; 65841-762; 70954-034; 12658-0359; 51991-885; 70954-033; 42291-103; 23155-120; 71205-308; 12658-0592; 72789-238; 51991-884; 51672-4023; 62332-349; 16729-331; 51927-2276; 23155-787; 23155-313; 64380-834; 67123-001; 12658-0593; 50090-5945; 70756-720; 72888-048; 63629-1195; 23155-288; 50090-5593; 51927-0200; 50742-233; 60687-578; 0143-9006; 72789-045; 50090-0577; 50090-5617; 63629-1194; 71335-1370; 55289-720; 70771-1490; 52817-201; 71930-008; 63629-8257; 12658-0591; 50090-5217; 29033-030; 12817-363; 0527-1050; 70934-926; 46708-349; 64380-833; 71930-009; 60687-619; 72888-047; 50090-3003; 50268-054; 23155-287; 52817-200; 51672-4022; 68382-076; 62991-2517; 72789-237; 14593-801; 39822-0190; 68084-541; 70756-721; 38779-0410; 42419-008; 42291-089; 63629-7889; 50090-4511; 70710-1591; 49452-0018; 50090-3132
Synonyms Acetazolamide | Acetazolam | Acetazolamide Sodium, (Sterile) | Acetazolamide, Monosodium Salt | Ak-Zol | Ak Zol | AkZol | Apo-Acetazolamide | Apo Acetazolamide | ApoAcetazolamide | Diacarb | Diamox | Diuramide | Défiltran | Edemox | Glauconox | Glaupax | Huma-Zolamide | Huma Zolamide | HumaZolamide | Acetadiazol
Chemical Information
Molecular Formula C4H6N4O3S2
CAS Registry Number 59-66-5
SMILES CC(=O)NC1=NN=C(S1)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site pain08.02.03.010; 12.07.03.011--Not Available
Irritability08.01.03.011; 19.04.02.013--
Jaundice cholestatic09.01.01.005--Not Available
Leukopenia01.02.02.001--Not Available
Malaise08.01.01.003--
Melaena07.12.02.004; 24.07.02.013--Not Available
Metabolic acidosis14.01.01.003--Not Available
Myopia06.02.04.002--Not Available
Nausea07.01.07.001--
Osteomalacia14.04.04.001; 15.02.03.001; 20.01.01.002--Not Available
Paraesthesia17.02.06.005--
Paralysis17.01.04.004--Not Available
Photosensitivity reaction23.03.09.003--
Polydipsia05.03.03.002; 14.05.02.001--Not Available
Polyuria20.02.03.002--Not Available
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Shock24.06.02.002--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Stevens-Johnson syndrome10.01.03.020; 11.07.01.005; 12.03.01.014; 23.03.01.007--
Thirst08.01.09.021; 14.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombocytopenic purpura01.08.01.003; 23.06.01.007--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Toxic epidermal necrolysis10.01.01.006; 11.07.01.006; 12.03.01.015; 23.03.01.008--
Urticaria10.01.06.001; 23.04.02.001--
Vomiting07.01.07.003--
Hypoacusis04.02.01.006--
Growth retardation15.03.01.006--
Urine output increased13.13.03.002--Not Available
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ADReCS-Target
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