Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abiraterone
Drug ID BADD_D00014
Description Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Indications and Usage Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
Marketing Status approved
ATC Code L02BX03
DrugBank ID DB05812
KEGG ID Not Available
MeSH ID C089740
PubChem ID 132971
TTD Drug ID D02STN
NDC Product Code 42291-024; 42291-073; 69238-1754; 60219-1754; 60687-455; 17337-0082; 54893-0070; 30007-838; 69238-1165; 60219-1165
UNII G819A456D0
Synonyms abiraterone | 17-(3-pyridyl)androsta-5,16-dien-3beta-ol | CB-7598 | CB 7598 | CB7598
Chemical Information
Molecular Formula C24H31NO
CAS Registry Number 154229-19-3
SMILES CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neoplasm progression16.16.02.005---
Spinal cord disorder17.10.01.0100.000734%-
Sudden hearing loss04.02.01.0090.000334%-
Decreased appetite08.01.09.028; 14.03.01.0050.031733%
Renal injury12.01.05.001; 20.01.03.0150.000501%-
Intervertebral disc disorder15.10.01.0030.000334%-
Urinary tract obstruction20.08.01.0040.002002%
Blood disorder01.05.01.0040.001468%-
Adverse drug reaction08.06.01.0090.019287%-
Bone lesion15.02.04.0160.001168%-
Disease progression08.01.03.0380.107744%
Gastrointestinal obstruction07.13.01.0050.000334%-
Hepatic lesion09.01.08.0050.000334%-
Metastasis16.22.01.0010.002402%-
Peripheral arterial occlusive disease24.04.03.0100.000334%-
Haemorrhagic diathesis01.01.03.003; 24.07.01.0200.000334%-
Hypophagia07.01.06.010; 14.03.01.006; 19.09.01.0040.003270%-
Gastrointestinal inflammation07.08.03.0070.001135%-
Skin haemorrhage23.06.07.001; 24.07.01.1030.000901%-
Osteonecrosis of jaw15.02.04.010; 24.04.05.0050.002402%
Urethral stenosis20.07.03.0030.000734%-
Penile oedema21.12.01.0070.000501%-
Liver injury09.01.07.022; 12.01.17.0120.001735%-
Adverse reaction08.06.01.0180.002136%-
Head and neck cancer16.16.01.0030.000334%-
Hypertransaminasaemia09.01.02.0050.000667%-
Tumour compression16.32.03.0210.000734%-
Drug-induced liver injury09.01.07.023; 12.03.01.0440.003904%-
Cholangitis acute09.02.01.0060.000334%-
Hyperaldosteronism05.01.01.006; 14.05.04.006; 24.08.04.0050.000334%-
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