Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Malignant glioma
ADR ID BADD_A10344
ADR Hierarchy
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.30      Nervous system neoplasms malignant and unspecified NEC
16.30.02      Glial tumours malignant
16.30.02.003      Malignant glioma
17      Nervous system disorders
17.20      Nervous system neoplasms malignant and unspecified NEC
17.20.02      Glial tumours malignant
17.20.02.003      Malignant glioma
Description Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21) [MeSH]
MedDRA Code 10065443
MeSH ID D005910
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Malignant glioma | IDH-mutant diffuse glioma with homozygous CDK2NA/B deletion | Diffuse hemispheric glioma, H3 G34-mutant | Diffuse pediatric high grade glioma, H3/IDH wildtype | Diffuse paediatric high grade glioma, H3/IDH wildtype | Glioma | Gliomas | Glial Cell Tumors | Glial Cell Tumor | Tumor, Glial Cell | Tumors, Glial Cell | Mixed Glioma | Glioma, Mixed | Gliomas, Mixed | Mixed Gliomas | Malignant Glioma | Glioma, Malignant | Gliomas, Malignant | Malignant Gliomas
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00371Carmustine0.000112%
BADD_D00566Dabrafenib0.000168%
BADD_D00680Dimethyl fumarate0.000400%
BADD_D02150Temozolomide0.000112%
BADD_D02526Larotrectinib0.000112%
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