Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Immunoglobulin G4 related disease
ADR ID BADD_A10115
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.06      Connective tissue disorders (excl congenital)
15.06.01      Connective tissue disorders NEC
15.06.01.020      Immunoglobulin G4 related disease
10      Immune system disorders
10.04      Autoimmune disorders
10.04.04      Autoimmune disorders NEC
10.04.04.028      Immunoglobulin G4 related disease
Description A spectrum of systemic autoimmune diseases in which IMMUNOGLOBULIN G4 plays a pathophysiologic role. It can affect multiple organs in highly variable presentations, characterized by inflammatory lesions composed of IgG4-positive PLASMA CELLS, further infiltrated by T helper cells (T-LYMPHOCYTES, HELPER-INDUCER) when linked to progressive FIBROSIS and eventual organ damage. [MeSH]
MedDRA Code 10077271
MeSH ID D000077733
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Immunoglobulin G4 related sclerosing disease | IgG4 related sclerosing disease | Immunoglobulin G4 related disease | Immunoglobulin G4-Related Disease | G4-Related Disease, Immunoglobulin | G4-Related Diseases, Immunoglobulin | Immunoglobulin G4 Related Disease | Immunoglobulin G4-Related Diseases | IgG4 Related Systemic Disease | IgG4-RD | IgG4-Associated Autoimmune Disease | Autoimmune Disease, IgG4-Associated | Autoimmune Diseases, IgG4-Associated | IgG4 Associated Autoimmune Disease | IgG4-Associated Autoimmune Diseases | IgG4-Related Disease | IgG4 Related Disease | IgG4-Related Diseases
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00195Azathioprine0.000313%
BADD_D01470Minocycline--
BADD_D01831Prednisolone0.000052%
BADD_D01834Prednisone0.000013%
BADD_D02053Sofosbuvir0.000282%
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