| ADR Ontology |
| ADR Term |
Dermal sinus |
| ADR ID |
BADD_A09784 |
| ADR Hierarchy |
|
| Description |
A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34) [MeSH] |
| MedDRA Code |
10012428 |
| MeSH ID |
D016136
|
|
ADR Severity Grade (FAERS)
|
|
|
ADR Severity Grade (CTCAE)
|
Not Available
|
| Synonym |
| Dermal sinus | Spina Bifida Occulta | Spinal Bifida, Closed | Closed Spinal Bifida | Occult Spina Bifida | Spina Bifida, Occult | Dermal Sinus | Sinus, Dermal |
|
|
| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D00066 | Alendronic acid | 0.000198% | | | BADD_D02392 | Zoledronic acid | 0.004294% | |
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