Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Chronic kidney disease-mineral and bone disorder
ADR ID BADD_A09697
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.02      Bone disorders (excl congenital and fractures)
15.02.03      Metabolic bone disorders
15.02.03.018      Chronic kidney disease-mineral and bone disorder
14      Metabolism and nutrition disorders
14.04      Bone, calcium, magnesium and phosphorus metabolism disorders
14.04.04      Bone metabolism disorders
14.04.04.017      Chronic kidney disease-mineral and bone disorder
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.01      Renal failure complications
20.01.01.012      Chronic kidney disease-mineral and bone disorder
Description Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders. [MeSH]
MedDRA Code 10078095
MeSH ID D012080
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Renal osteodystrophy | Renal osteopathy syndrome | Chronic kidney disease-mineral and bone disorder | CKD-MBD | Chronic Kidney Disease-Mineral and Bone Disorder | Chronic Kidney Disease Mineral and Bone Disorder | Renal Osteodystrophy | Osteodystrophies, Renal | Renal Osteodystrophies | Osteodystrophy, Renal | Renal Rickets | Rickets, Renal
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01508Mycophenolic acid0.000951%
BADD_D02192Thalidomide0.000241%
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