Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Stiff person syndrome
ADR ID BADD_A09147
ADR Hierarchy
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.02      Muscle tone abnormal
17.05.02.018      Stiff person syndrome
10      Immune system disorders
10.04      Autoimmune disorders
10.04.10      Nervous system autoimmune disorders
10.04.10.017      Stiff person syndrome
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.04      Muscle tone abnormalities
15.05.04.021      Stiff person syndrome
Description A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93) [MeSH]
MedDRA Code 10072148
MeSH ID D016750
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Stiff-man syndrome | Stiff person syndrome | Moersch-Woltman syndrome | Stiff-Person Syndrome | Stiff Person Syndrome | Syndrome, Stiff-Person | Stiff-Man Syndrome | Stiff Man Syndrome | Syndrome, Stiff-Man | Stiffman Syndrome | Syndrome, Stiffman | Stiff-Baby Syndrome | Stiff-Baby Syndromes | Syndrome, Stiff-Baby | Syndromes, Stiff-Baby | Congenital Stiff-Man Syndrome | Congenital Stiff Man Syndrome | Congenital Stiff-Man Syndromes | Stiff-Man Syndrome, Congenital | Stiff-Man Syndromes, Congenital | Syndrome, Congenital Stiff-Man | Syndromes, Congenital Stiff-Man | Congenital Stiff-Person Syndrome | Congenital Stiff-Person Syndromes | Stiff-Person Syndrome, Congenital | Stiff-Person Syndromes, Congenital | Syndrome, Congenital Stiff-Person | Syndromes, Congenital Stiff-Person | Startle Syndrome | Startle Syndromes | Syndrome, Startle | Syndromes, Startle | Moersch-Woltmann Syndrome | Moersch Woltmann Syndrome | Syndrome, Moersch-Woltmann | Stiff-Trunk Syndrome | Stiff Trunk Syndrome | Stiff-Trunk Syndromes | Syndrome, Stiff-Trunk | Syndromes, Stiff-Trunk | Familial Hyperekplexia | Familial Hyperekplexias | Hyperekplexia, Familial | Hyperekplexias, Familial | Hereditary Hyperekplexia | Hereditary Hyperekplexias | Hyperekplexia, Hereditary | Hyperekplexias, Hereditary
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00475Citalopram--
BADD_D00648Diazepam0.000050%
BADD_D00734Duloxetine0.000173%
BADD_D00809Escitalopram0.000038%
BADD_D02010Sertraline0.000013%
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